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- W2410834246 abstract "Abstract Recent reports indicate that certain prostaglandins are effective abortifacients through their oxytocic activity. In this study, 10 women, 10 to 15 weeks pregnant, received prostaglandin F 2α (PGF 2α ) by intravenous infusion for termination of pregnancy. Complete abortion was achieved in 9 cases with a mean induction-abortion interval of 24 hours, 41 minutes and a mean drug dose of 93.5 mg. An infusion rate of 50 μg per minute was sufficient to induce uterine activity adequate for abortion. The incidence of side effects at this dosage level was high. Electrocardiogram changes and pyrexia were more pronounced at higher infusion rates. Plasma progesterone levels fell only after abortion. Mean plasma PGF 2α levels before infusion were 0.40 ng. per milliliter and increased significantly with increases in infusion rate to a mean level of 3.00 ng. per millititer at 200 μg per minute. Mean plasma PGF 2α levels double the preinfusion levels appeared sufficient to initiate adequate uterine activity. We conclude that, although intravenous PGF 2α is an effective abortifacient, this method of delivery has limited clinical usefulness." @default.
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- W2410834246 date "1972-02-01" @default.
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- W2410834246 title "Therapeutic abortion with the use of prostaglandin F2α" @default.
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- W2410834246 doi "https://doi.org/10.1016/0002-9378(72)90472-3" @default.
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