Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410839930> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2410839930 endingPage "17" @default.
- W2410839930 startingPage "405" @default.
- W2410839930 abstract "In the present investigation we have determined the effects of the differentiation-inducing chemicals dimethyl sulfoxide (DMSO) and sodium butyrate on the growth and tumorigenicity of a highly malignant/metastatic cell line (RAW117-H10) and its less tumorigenic parental lymphoma cell line (RAW117-P). Both of these agents at doses shown to be nontoxic slowed the growth of these cells in suspension culture and significantly lengthened the doubling time while reducing colony formation in the agar tumor stem cell assay. Corresponding to these observations, the in vivo tumorigenicity of the highly malignant RAW117-H10 line was reduced by both chemicals but particularly by butyrate treatment. In addition, both agents increased the expression of some glycoproteins and the glycolipid asialo GM1. There was also a corresponding increase in the NK susceptibility of the normally NK resistant RAW117-H10 cells. To determine if the decreased malignancy of the highly malignant cells following treatment with the chemical agents was primarily due to the alteration in cell surface glycoconjugates or merely due to concomitant decreased growth potential, we transplanted highly glycosylated membrane fragments from normal syngeneic thymocytes to both RAW117-P and RAW117-H10 cells using a Sendai virus mediated membrane fusion technique. The in vivo tumorigenicity of the membrane altered RAW117-H10 cells was significantly decreased. These results strongly suggest that the decreased in vivo malignancy of RAW117-H10 cells resulting from treatment with chemical differentiation agents is caused by their increased susceptibility to NK cell mediated lysis which in turn results from cell surface changes involving altered, primarily increased, expression of certain glycosylated surface molecules. The cell surface glycoconjugates, such as receptors for certain lectins and glycolipid asialo GM1, can be used as markers for malignant potential and NK sensitivity of malignant lymphoid cells." @default.
- W2410839930 created "2016-06-24" @default.
- W2410839930 creator A5000190434 @default.
- W2410839930 creator A5007517045 @default.
- W2410839930 creator A5023254583 @default.
- W2410839930 creator A5046772826 @default.
- W2410839930 creator A5067292776 @default.
- W2410839930 creator A5072048181 @default.
- W2410839930 date "1988-01-01" @default.
- W2410839930 modified "2023-09-26" @default.
- W2410839930 title "Effects of differentiation inducing chemicals on in vivo malignancy and NK susceptibility of metastatic lymphoma cells." @default.
- W2410839930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3390859" @default.
- W2410839930 hasPublicationYear "1988" @default.
- W2410839930 type Work @default.
- W2410839930 sameAs 2410839930 @default.
- W2410839930 citedByCount "7" @default.
- W2410839930 countsByYear W24108399302012 @default.
- W2410839930 countsByYear W24108399302015 @default.
- W2410839930 crossrefType "journal-article" @default.
- W2410839930 hasAuthorship W2410839930A5000190434 @default.
- W2410839930 hasAuthorship W2410839930A5007517045 @default.
- W2410839930 hasAuthorship W2410839930A5023254583 @default.
- W2410839930 hasAuthorship W2410839930A5046772826 @default.
- W2410839930 hasAuthorship W2410839930A5067292776 @default.
- W2410839930 hasAuthorship W2410839930A5072048181 @default.
- W2410839930 hasConcept C100544194 @default.
- W2410839930 hasConcept C13426554 @default.
- W2410839930 hasConcept C1491633281 @default.
- W2410839930 hasConcept C150903083 @default.
- W2410839930 hasConcept C185592680 @default.
- W2410839930 hasConcept C207001950 @default.
- W2410839930 hasConcept C2776127477 @default.
- W2410839930 hasConcept C2776979534 @default.
- W2410839930 hasConcept C2778942008 @default.
- W2410839930 hasConcept C502942594 @default.
- W2410839930 hasConcept C54355233 @default.
- W2410839930 hasConcept C55493867 @default.
- W2410839930 hasConcept C62112901 @default.
- W2410839930 hasConcept C81885089 @default.
- W2410839930 hasConcept C86803240 @default.
- W2410839930 hasConcept C92488253 @default.
- W2410839930 hasConcept C95444343 @default.
- W2410839930 hasConceptScore W2410839930C100544194 @default.
- W2410839930 hasConceptScore W2410839930C13426554 @default.
- W2410839930 hasConceptScore W2410839930C1491633281 @default.
- W2410839930 hasConceptScore W2410839930C150903083 @default.
- W2410839930 hasConceptScore W2410839930C185592680 @default.
- W2410839930 hasConceptScore W2410839930C207001950 @default.
- W2410839930 hasConceptScore W2410839930C2776127477 @default.
- W2410839930 hasConceptScore W2410839930C2776979534 @default.
- W2410839930 hasConceptScore W2410839930C2778942008 @default.
- W2410839930 hasConceptScore W2410839930C502942594 @default.
- W2410839930 hasConceptScore W2410839930C54355233 @default.
- W2410839930 hasConceptScore W2410839930C55493867 @default.
- W2410839930 hasConceptScore W2410839930C62112901 @default.
- W2410839930 hasConceptScore W2410839930C81885089 @default.
- W2410839930 hasConceptScore W2410839930C86803240 @default.
- W2410839930 hasConceptScore W2410839930C92488253 @default.
- W2410839930 hasConceptScore W2410839930C95444343 @default.
- W2410839930 hasIssue "3-6" @default.
- W2410839930 hasLocation W24108399301 @default.
- W2410839930 hasOpenAccess W2410839930 @default.
- W2410839930 hasPrimaryLocation W24108399301 @default.
- W2410839930 hasRelatedWork W2008365238 @default.
- W2410839930 hasRelatedWork W2032209516 @default.
- W2410839930 hasRelatedWork W2037905000 @default.
- W2410839930 hasRelatedWork W2356448472 @default.
- W2410839930 hasRelatedWork W2364271926 @default.
- W2410839930 hasRelatedWork W2379833382 @default.
- W2410839930 hasRelatedWork W2406842358 @default.
- W2410839930 hasRelatedWork W2410839930 @default.
- W2410839930 hasRelatedWork W2442207534 @default.
- W2410839930 hasRelatedWork W3029744252 @default.
- W2410839930 hasVolume "11" @default.
- W2410839930 isParatext "false" @default.
- W2410839930 isRetracted "false" @default.
- W2410839930 magId "2410839930" @default.
- W2410839930 workType "article" @default.