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- W2410918129 endingPage "156" @default.
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- W2410918129 abstract "The Long INterspersed Element-1 (LINE-1 or L1) retrotransposition assay has facilitated the discovery and characterization of active (i.e., retrotransposition-competent) LINE-1 sequences from mammalian genomes. In this assay, an engineered LINE-1 containing a retrotransposition reporter cassette is transiently transfected into a cultured cell line. Expression of the reporter cassette, which occurs only after a successful round of retrotransposition, allows the detection and quantification of the LINE-1 retrotransposition efficiency. This assay has yielded insight into the mechanism of LINE-1 retrotransposition. It also has provided a greater understanding of how the cell regulates LINE-1 retrotransposition and how LINE-1 retrotransposition impacts the structure of mammalian genomes. Below, we provide a brief introduction to LINE-1 biology and then detail how the LINE-1 retrotransposition assay is performed in cultured mammalian cells." @default.
- W2410918129 created "2016-06-24" @default.
- W2410918129 creator A5012243336 @default.
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- W2410918129 creator A5086522262 @default.
- W2410918129 date "2016-01-01" @default.
- W2410918129 modified "2023-10-01" @default.
- W2410918129 title "LINE-1 Cultured Cell Retrotransposition Assay" @default.
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- W2410918129 doi "https://doi.org/10.1007/978-1-4939-3372-3_10" @default.
- W2410918129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5070806" @default.
- W2410918129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26895052" @default.
- W2410918129 hasPublicationYear "2016" @default.
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