Matches in SemOpenAlex for { <https://semopenalex.org/work/W2410930067> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2410930067 endingPage "4" @default.
- W2410930067 startingPage "S41" @default.
- W2410930067 abstract "The pathogenesis of protein wasting in chronic renal failure is multifactorial. Potential mediators of protein catabolism in chronic uremia include anorexia, low protein-energy intake, increased cortisol and parathyroid hormone secretion, insulin resistance, metabolic acidosis and unidentified uremic toxins. In non-acidotic uremic patients the rate of protein turnover (that is, synthesis and degradation) has often been found to be decreased. Malnutrition also decreases both protein synthesis and degradation. In contrast, during acidosis protein degradation is primarily accelerated and results in rapid loss of body proteins. Cytokine concentrations have often been found increased in both dialyzed and undialyzed chronically uremic patients. Our study determined the circulating levels of TNF-alpha and of type I (60 kDa) and type II (80 kDa) soluble TNF-alpha receptors in undialyzed uremic patients, and found that their plasma levels were greatly increased. Serum creatinine correlated with TNF-alpha soluble receptors but not with the TNF-alpha. Thus, TNF-alpha is potentially an important mediator of protein wasting in chronically uremic patients. Pharmacological therapy of protein catabolism in chronic uremia may include the administration of pentoxifylline, which has been shown to decrease protein degradation by interfering with the TNF-alpha system (that is, TNF-alpha and its soluble receptors) in experimental models. Growth hormone and insulin-like growth factor-1 administration may also be beneficial in these patients, but further evaluation of the hormone effects on glucose and glutamine metabolism is called for." @default.
- W2410930067 created "2016-06-24" @default.
- W2410930067 creator A5019041011 @default.
- W2410930067 creator A5025489246 @default.
- W2410930067 creator A5028774511 @default.
- W2410930067 creator A5040625595 @default.
- W2410930067 creator A5043866664 @default.
- W2410930067 creator A5045242883 @default.
- W2410930067 creator A5064513945 @default.
- W2410930067 creator A5069463295 @default.
- W2410930067 creator A5081926215 @default.
- W2410930067 creator A5058332269 @default.
- W2410930067 date "1997-11-01" @default.
- W2410930067 modified "2023-09-29" @default.
- W2410930067 title "Mechanisms of malnutrition in uremia." @default.
- W2410930067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9350678" @default.
- W2410930067 hasPublicationYear "1997" @default.
- W2410930067 type Work @default.
- W2410930067 sameAs 2410930067 @default.
- W2410930067 citedByCount "11" @default.
- W2410930067 countsByYear W24109300672018 @default.
- W2410930067 crossrefType "journal-article" @default.
- W2410930067 hasAuthorship W2410930067A5019041011 @default.
- W2410930067 hasAuthorship W2410930067A5025489246 @default.
- W2410930067 hasAuthorship W2410930067A5028774511 @default.
- W2410930067 hasAuthorship W2410930067A5040625595 @default.
- W2410930067 hasAuthorship W2410930067A5043866664 @default.
- W2410930067 hasAuthorship W2410930067A5045242883 @default.
- W2410930067 hasAuthorship W2410930067A5058332269 @default.
- W2410930067 hasAuthorship W2410930067A5064513945 @default.
- W2410930067 hasAuthorship W2410930067A5069463295 @default.
- W2410930067 hasAuthorship W2410930067A5081926215 @default.
- W2410930067 hasConcept C126322002 @default.
- W2410930067 hasConcept C134018914 @default.
- W2410930067 hasConcept C197683979 @default.
- W2410930067 hasConcept C2776635150 @default.
- W2410930067 hasConcept C2779764123 @default.
- W2410930067 hasConcept C2992195973 @default.
- W2410930067 hasConcept C515207424 @default.
- W2410930067 hasConcept C55493867 @default.
- W2410930067 hasConcept C62231903 @default.
- W2410930067 hasConcept C71924100 @default.
- W2410930067 hasConcept C86803240 @default.
- W2410930067 hasConcept C96942376 @default.
- W2410930067 hasConceptScore W2410930067C126322002 @default.
- W2410930067 hasConceptScore W2410930067C134018914 @default.
- W2410930067 hasConceptScore W2410930067C197683979 @default.
- W2410930067 hasConceptScore W2410930067C2776635150 @default.
- W2410930067 hasConceptScore W2410930067C2779764123 @default.
- W2410930067 hasConceptScore W2410930067C2992195973 @default.
- W2410930067 hasConceptScore W2410930067C515207424 @default.
- W2410930067 hasConceptScore W2410930067C55493867 @default.
- W2410930067 hasConceptScore W2410930067C62231903 @default.
- W2410930067 hasConceptScore W2410930067C71924100 @default.
- W2410930067 hasConceptScore W2410930067C86803240 @default.
- W2410930067 hasConceptScore W2410930067C96942376 @default.
- W2410930067 hasLocation W24109300671 @default.
- W2410930067 hasOpenAccess W2410930067 @default.
- W2410930067 hasPrimaryLocation W24109300671 @default.
- W2410930067 hasRelatedWork W1982685226 @default.
- W2410930067 hasRelatedWork W1991453182 @default.
- W2410930067 hasRelatedWork W1992523552 @default.
- W2410930067 hasRelatedWork W2053537644 @default.
- W2410930067 hasRelatedWork W2074902791 @default.
- W2410930067 hasRelatedWork W2076544608 @default.
- W2410930067 hasRelatedWork W2096523173 @default.
- W2410930067 hasRelatedWork W2119527577 @default.
- W2410930067 hasRelatedWork W2413036141 @default.
- W2410930067 hasRelatedWork W40611714 @default.
- W2410930067 hasVolume "62" @default.
- W2410930067 isParatext "false" @default.
- W2410930067 isRetracted "false" @default.
- W2410930067 magId "2410930067" @default.
- W2410930067 workType "article" @default.