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- W2411014367 abstract "The objective of the present research was to prepare fast disintegrating tablets of atenolol, because of its application in hypertension and other heart related problems, fast onset of action and avoidance of water which is highly desirable in this type of disease conditions. During the work tablets were prepared by direct compression using croscarmllose as superdisintegrant and polyvinyl pyrrolidone as filler. Mannitol, amaranth and menthol crystal were used to enhance the organoleptic properties of tablets. The different powder blends were evaluated for pre compression parameters such as bulk density, tapped density, angle of repose, Carr’s index and dispersibility. The tablets were evaluated for post-compression parameters such as weight variation, mechanical strength, thickness, wetting profile, in vitro disintegration time, and drug release characteristics. All the physical characters of powder blend and fabricated tablet were within acceptable limits. The results of in vitro disintegration time indicated that the tablets dispersed rapidly in mouth. It was concluded from the result that combination of croscormillose and polyvinyl pyrrolidone in a particular manner is a useful method for preparing fast disintegrating tablets by direct compression method. So this technique can be used at industrial level for the commercialization of fast disintegrating tablet formulation in a specific disease condition." @default.
- W2411014367 created "2016-06-24" @default.
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- W2411014367 date "2010-01-01" @default.
- W2411014367 modified "2023-09-24" @default.
- W2411014367 title "FORMULATION DEVELOPMENT AND EVALUATION OF ATENOLOL FAST DISINTEGRATING TABLETS FOR TREATMENT OF HYPERTENSION" @default.
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