Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411145041> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2411145041 endingPage "14" @default.
- W2411145041 startingPage "509" @default.
- W2411145041 abstract "Mechanisms for cisplatin resistance were studied using mouse leukemias acquired resistance to the drug. Uptakes of cisplatin by L-1210/DDP and P 388/DDP were significantly decreased, compared with the respective sensitive lines. Glutathione contents in both the resistant lines were 1.7 times more than in the respective sensitive ones. While glutathione contents were reduced to about 10% by incubation of cells with D, L-buthionine-S, R-sulfoximine, sensitivity of the resistant cells remained unchanged. Therefore, glutathione might not relate to the mechanism for resistance in these lines. Cross-resistance patterns of L-1210/DDP and P 388/DDP as well as Colon 26/DDP to cisplatin analogs were investigated. Carrier ligands of the analogs, by which antitumor spectra would be controlled, were different from each other and leaving groups were Cl2, as a rule. As a result, L-1210/DDP showed cross-resistance only to two analogs. In contrast, P 388/DDP did so to all complexes tested. The resistance indices to four analogs were more than 50. Colon 26/DDP also showed cross-resistance to all of them, but the degrees of resistance in this line were lower than those in P 388/DDP. These facts revealed that the pattern of cross-resistance was dependent on each cell line and the completely different patterns were shown between the mouse leukemia resistant lines. It was suggested that in developing a new platinum analog, we should select a carrier ligand to which as many resistant lines would show lack of cross-resistance." @default.
- W2411145041 created "2016-06-24" @default.
- W2411145041 creator A5084370228 @default.
- W2411145041 date "1990-03-01" @default.
- W2411145041 modified "2023-09-23" @default.
- W2411145041 title "[Mechanisms for resistance and cross-resistance patterns of cisplatin-resistant tumor lines]." @default.
- W2411145041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2321979" @default.
- W2411145041 hasPublicationYear "1990" @default.
- W2411145041 type Work @default.
- W2411145041 sameAs 2411145041 @default.
- W2411145041 citedByCount "0" @default.
- W2411145041 crossrefType "journal-article" @default.
- W2411145041 hasAuthorship W2411145041A5084370228 @default.
- W2411145041 hasConcept C109316439 @default.
- W2411145041 hasConcept C114851261 @default.
- W2411145041 hasConcept C153911025 @default.
- W2411145041 hasConcept C181199279 @default.
- W2411145041 hasConcept C185592680 @default.
- W2411145041 hasConcept C202751555 @default.
- W2411145041 hasConcept C25642318 @default.
- W2411145041 hasConcept C2776694085 @default.
- W2411145041 hasConcept C2777476445 @default.
- W2411145041 hasConcept C2778080818 @default.
- W2411145041 hasConcept C2778239845 @default.
- W2411145041 hasConcept C502942594 @default.
- W2411145041 hasConcept C538909803 @default.
- W2411145041 hasConcept C54355233 @default.
- W2411145041 hasConcept C55493867 @default.
- W2411145041 hasConcept C81885089 @default.
- W2411145041 hasConcept C86803240 @default.
- W2411145041 hasConceptScore W2411145041C109316439 @default.
- W2411145041 hasConceptScore W2411145041C114851261 @default.
- W2411145041 hasConceptScore W2411145041C153911025 @default.
- W2411145041 hasConceptScore W2411145041C181199279 @default.
- W2411145041 hasConceptScore W2411145041C185592680 @default.
- W2411145041 hasConceptScore W2411145041C202751555 @default.
- W2411145041 hasConceptScore W2411145041C25642318 @default.
- W2411145041 hasConceptScore W2411145041C2776694085 @default.
- W2411145041 hasConceptScore W2411145041C2777476445 @default.
- W2411145041 hasConceptScore W2411145041C2778080818 @default.
- W2411145041 hasConceptScore W2411145041C2778239845 @default.
- W2411145041 hasConceptScore W2411145041C502942594 @default.
- W2411145041 hasConceptScore W2411145041C538909803 @default.
- W2411145041 hasConceptScore W2411145041C54355233 @default.
- W2411145041 hasConceptScore W2411145041C55493867 @default.
- W2411145041 hasConceptScore W2411145041C81885089 @default.
- W2411145041 hasConceptScore W2411145041C86803240 @default.
- W2411145041 hasIssue "3 Pt 2" @default.
- W2411145041 hasLocation W24111450411 @default.
- W2411145041 hasOpenAccess W2411145041 @default.
- W2411145041 hasPrimaryLocation W24111450411 @default.
- W2411145041 hasRelatedWork W2001407902 @default.
- W2411145041 hasRelatedWork W2007037758 @default.
- W2411145041 hasRelatedWork W2039745908 @default.
- W2411145041 hasRelatedWork W2073697967 @default.
- W2411145041 hasRelatedWork W2327068644 @default.
- W2411145041 hasRelatedWork W2396145710 @default.
- W2411145041 hasRelatedWork W2402222699 @default.
- W2411145041 hasRelatedWork W2411145041 @default.
- W2411145041 hasRelatedWork W3049295356 @default.
- W2411145041 hasRelatedWork W1648648517 @default.
- W2411145041 hasVolume "17" @default.
- W2411145041 isParatext "false" @default.
- W2411145041 isRetracted "false" @default.
- W2411145041 magId "2411145041" @default.
- W2411145041 workType "article" @default.