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- W2411345369 abstract "Objective To observe the effect of electroacupuncture(EA) on the expression of ionotropic glutamate receptor(iGluR) subunits and their mRNAs in the lumbar segments of spinal cord in rats with neuropathic pain,so as to explore its underlying mechanism in relieving spinal hyperalgesia.Methods Thirty SD rats were randomly divided into control,model,and EA groups,with 10 rats in each.The spared nerve injury(SNI) model was established by ligature of the sural nerve after cutting off the common peroneal nerve and anterior tibial nerve.EA(2Hz,1mA) was applied to Huantiao(GB30) and Weizhong(BL40) for 30min,once daily for 7 days.Mechanical pain threshold was detected before and after modeling and before and after EA treatment.The expression levels of N-methyl-d-aspartic acid(NMDA) receptor subunits NR1 and NR2B,and AMPA receptor subunit GluR1 of iGluR and their genes were assayed by Western blot and reverse transcription polymerase chain reaction(RT-PCR) separately.Results In comparison with control group,the mechanical pain thresholds were decreased significantly on day 2,7 and day 14 following modeling in the model group(P0.05,P0.01).While compared with the model group,the pain threshold was increased considerably on day 14 in the EA group(P0.01).Compared with the control group,the expression levels of lumbar spinal cord NR2B and NR2B mRNA in the model group were increased significantly(P0.05),and those of lumbar spinal cord NR1 and NR1 mRNA,GluR1 and GluR1 mRNA in the model group increased slightly(P0.05).In comparison with the model group,the expression levels of lumbar spinal cord NR2B and NR2B mRNA in the EA group were down-regulated remarkably(P0.05),and those of lumbar spinal cord NR1 and NR1 mRNA,GluR1 and GluR1 mRNA in the EA group down-regulated slightly(P0.05).Conclusion EA can significantly suppress pain reaction in rats with neuropathic pain proba-bly through down-regulating the expression of lumbar spinal cord NR2B protein and NR2B mRNA." @default.
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- W2411345369 date "2010-12-01" @default.
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- W2411345369 title "Effect of electroacupuncture on expression of ionotropic glutamate receptor subunits and their genes in lumbar segments of spinal cord in rats with neuropathic pain" @default.
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