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- W2411350502 abstract "Publisher Summary This chapter describes clinical aspects of L -Asparaginase. L -Asparaginase catalyzes the hydrolysis of asparagine to form aspartic acid and NH 3 . The reaction is not reversible. Asparaginase is present in many animal tissues, bacteria and plants. It is found in the serum of guinea pigs and certain rodents, but not in that of man. The enzyme from Escherichia coli exists in two fractions (EC-1 and EC-2), separable by elution with a continuous sodium chloride gradient from a DEAE-cellulose column. L -Asparaginase from E. coli (EC-2), from guinea pig serum and, to a lesser extent, that purified from chicken liver, inhibit the growth of certain lymphomas and leukemias of mice, rats, and dogs. Tumors that are sensitive to E. coli L -asparaginase have low levels of asparagine synthetase and presumably require an exogenous source of L -asparagine. During the administration of the enzyme to patients it is necessary to monitor serum or plasma levels to demonstrate the effective therapeutic dose. Thus, the clinical importance of this enzyme assay is not for diagnostic purposes, but rather to measure the enzyme when it is used as a drug." @default.
- W2411350502 created "2016-06-24" @default.
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- W2411350502 date "1971-01-01" @default.
- W2411350502 modified "2023-09-27" @default.
- W2411350502 title "[261b] Clinical aspects of l-asparaginase" @default.
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- W2411350502 doi "https://doi.org/10.1016/0076-6879(71)17154-6" @default.
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