Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411363355> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2411363355 endingPage "60" @default.
- W2411363355 startingPage "57" @default.
- W2411363355 abstract "The digoxin level in the blood was determined in 92 patients with blood circulatory insufficiency using radioimmunoassays (Sea Ire-Sorin kits) and radionuclide (86 Rb) methods. Pharmacokinetics of digoxin was evaluated on the basis of a two-compartmental mathematical model (by J. Y. Wagner). Direct correlation between the value of a maintenance dose and digoxin concentration in the blood was established. Digoxin values in the blood determined by the radionuclide method, were somewhat higher than the indices of the radioimmunological method. According to this method digoxin therapeutic concentrations in the blood were: 0.4-2.8 ng/ml; according to the radionuclide method 0.6-4.8 ng/ml. Symptoms of digoxin intoxication (overdosage) in rising its concentration in the blood up to 1.1-3.3 ng/ml by the radioimmunoassay and up to 2.2-6.1 ng/ml by the radionuclide method were recorded. It can be accounted for by the fact that bigger values of digoxin active metabolites are determined by the radionuclide method, whereas the radioimmunoassay is more specific to digoxin. Pharmacokinetic parameters (distribution volume, digoxin clearance, the period of semi-elimination) calculated by two methods, brought about the same results. Regularities of the changes of digoxin pharmacokinetics in patients with disturbed renal function are analysed." @default.
- W2411363355 created "2016-06-24" @default.
- W2411363355 creator A5020476827 @default.
- W2411363355 creator A5072289158 @default.
- W2411363355 date "1983-08-01" @default.
- W2411363355 modified "2023-09-23" @default.
- W2411363355 title "[Radionuclide methods of determining digoxin levels]." @default.
- W2411363355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6888212" @default.
- W2411363355 hasPublicationYear "1983" @default.
- W2411363355 type Work @default.
- W2411363355 sameAs 2411363355 @default.
- W2411363355 citedByCount "0" @default.
- W2411363355 crossrefType "journal-article" @default.
- W2411363355 hasAuthorship W2411363355A5020476827 @default.
- W2411363355 hasAuthorship W2411363355A5072289158 @default.
- W2411363355 hasConcept C112705442 @default.
- W2411363355 hasConcept C121332964 @default.
- W2411363355 hasConcept C126322002 @default.
- W2411363355 hasConcept C158973077 @default.
- W2411363355 hasConcept C176685330 @default.
- W2411363355 hasConcept C185592680 @default.
- W2411363355 hasConcept C2777707475 @default.
- W2411363355 hasConcept C2778198053 @default.
- W2411363355 hasConcept C62520636 @default.
- W2411363355 hasConcept C71924100 @default.
- W2411363355 hasConcept C98274493 @default.
- W2411363355 hasConceptScore W2411363355C112705442 @default.
- W2411363355 hasConceptScore W2411363355C121332964 @default.
- W2411363355 hasConceptScore W2411363355C126322002 @default.
- W2411363355 hasConceptScore W2411363355C158973077 @default.
- W2411363355 hasConceptScore W2411363355C176685330 @default.
- W2411363355 hasConceptScore W2411363355C185592680 @default.
- W2411363355 hasConceptScore W2411363355C2777707475 @default.
- W2411363355 hasConceptScore W2411363355C2778198053 @default.
- W2411363355 hasConceptScore W2411363355C62520636 @default.
- W2411363355 hasConceptScore W2411363355C71924100 @default.
- W2411363355 hasConceptScore W2411363355C98274493 @default.
- W2411363355 hasIssue "8" @default.
- W2411363355 hasLocation W24113633551 @default.
- W2411363355 hasOpenAccess W2411363355 @default.
- W2411363355 hasPrimaryLocation W24113633551 @default.
- W2411363355 hasRelatedWork W1969203961 @default.
- W2411363355 hasRelatedWork W1976971977 @default.
- W2411363355 hasRelatedWork W1995742773 @default.
- W2411363355 hasRelatedWork W2075428150 @default.
- W2411363355 hasRelatedWork W2129587982 @default.
- W2411363355 hasRelatedWork W2157262647 @default.
- W2411363355 hasRelatedWork W2354676291 @default.
- W2411363355 hasRelatedWork W2411363355 @default.
- W2411363355 hasRelatedWork W2464676443 @default.
- W2411363355 hasRelatedWork W2899084033 @default.
- W2411363355 hasVolume "28" @default.
- W2411363355 isParatext "false" @default.
- W2411363355 isRetracted "false" @default.
- W2411363355 magId "2411363355" @default.
- W2411363355 workType "article" @default.