Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411403746> ?p ?o ?g. }
- W2411403746 endingPage "874" @default.
- W2411403746 startingPage "862" @default.
- W2411403746 abstract "Facultative heterochromatin regulates gene expression, but its assembly is poorly understood. Previously, we identified facultative heterochromatin islands in the fission yeast genome and found that RNA elimination machinery promotes island assembly at meiotic genes. Here, we report that Taz1, a component of the telomere protection complex Shelterin, is required to assemble heterochromatin islands at regions corresponding to late replication origins that are sites of double-strand break formation during meiosis. The loss of Taz1 or other Shelterin subunits, including Ccq1 that interacts with Clr4/Suv39h, abolishes heterochromatin at late origins and causes derepression of associated genes. Moreover, the late-origin regulator Rif1 affects heterochromatin at Taz1-dependent islands and subtelomeric regions. We explore the connection between facultative heterochromatin and replication control and show that heterochromatin machinery affects replication timing. These analyses reveal the role of Shelterin in facultative heterochromatin assembly at late origins, which has important implications for genome stability and gene regulation." @default.
- W2411403746 created "2016-06-24" @default.
- W2411403746 creator A5020713009 @default.
- W2411403746 creator A5045723947 @default.
- W2411403746 creator A5064445924 @default.
- W2411403746 creator A5070269022 @default.
- W2411403746 creator A5070902809 @default.
- W2411403746 date "2016-06-01" @default.
- W2411403746 modified "2023-10-16" @default.
- W2411403746 title "Taz1-Shelterin Promotes Facultative Heterochromatin Assembly at Chromosome-Internal Sites Containing Late Replication Origins" @default.
- W2411403746 cites W1968917480 @default.
- W2411403746 cites W1969636175 @default.
- W2411403746 cites W1973057702 @default.
- W2411403746 cites W1985910710 @default.
- W2411403746 cites W1990265320 @default.
- W2411403746 cites W1992809368 @default.
- W2411403746 cites W1996800742 @default.
- W2411403746 cites W2000625991 @default.
- W2411403746 cites W2007452601 @default.
- W2411403746 cites W2010027764 @default.
- W2411403746 cites W2014766736 @default.
- W2411403746 cites W2021054808 @default.
- W2411403746 cites W2026887719 @default.
- W2411403746 cites W2027950141 @default.
- W2411403746 cites W2028795836 @default.
- W2411403746 cites W2030665161 @default.
- W2411403746 cites W2032379393 @default.
- W2411403746 cites W2035199905 @default.
- W2411403746 cites W2035564586 @default.
- W2411403746 cites W2036450305 @default.
- W2411403746 cites W2040234712 @default.
- W2411403746 cites W2046393794 @default.
- W2411403746 cites W2049266253 @default.
- W2411403746 cites W2049992533 @default.
- W2411403746 cites W2052770408 @default.
- W2411403746 cites W2054663548 @default.
- W2411403746 cites W2054923018 @default.
- W2411403746 cites W2062310052 @default.
- W2411403746 cites W2068363360 @default.
- W2411403746 cites W2075626800 @default.
- W2411403746 cites W2076828744 @default.
- W2411403746 cites W2084293680 @default.
- W2411403746 cites W2092938454 @default.
- W2411403746 cites W2099357999 @default.
- W2411403746 cites W2101089041 @default.
- W2411403746 cites W2102599158 @default.
- W2411403746 cites W2104199689 @default.
- W2411403746 cites W2105033032 @default.
- W2411403746 cites W2110926898 @default.
- W2411403746 cites W2112113834 @default.
- W2411403746 cites W2115851523 @default.
- W2411403746 cites W2117771255 @default.
- W2411403746 cites W2120055220 @default.
- W2411403746 cites W2120776332 @default.
- W2411403746 cites W2123588601 @default.
- W2411403746 cites W2127610747 @default.
- W2411403746 cites W2128320997 @default.
- W2411403746 cites W2132771408 @default.
- W2411403746 cites W2132779860 @default.
- W2411403746 cites W2134809769 @default.
- W2411403746 cites W2143658931 @default.
- W2411403746 cites W2145027935 @default.
- W2411403746 cites W2145125856 @default.
- W2411403746 cites W2146667434 @default.
- W2411403746 cites W2147500564 @default.
- W2411403746 cites W2154151985 @default.
- W2411403746 cites W2160185049 @default.
- W2411403746 cites W2163649668 @default.
- W2411403746 cites W2164719406 @default.
- W2411403746 cites W2166782230 @default.
- W2411403746 cites W2227559827 @default.
- W2411403746 cites W2291947335 @default.
- W2411403746 cites W2739174192 @default.
- W2411403746 cites W3211005720 @default.
- W2411403746 doi "https://doi.org/10.1016/j.molcel.2016.04.034" @default.
- W2411403746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6699828" @default.
- W2411403746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27264871" @default.
- W2411403746 hasPublicationYear "2016" @default.
- W2411403746 type Work @default.
- W2411403746 sameAs 2411403746 @default.
- W2411403746 citedByCount "60" @default.
- W2411403746 countsByYear W24114037462016 @default.
- W2411403746 countsByYear W24114037462017 @default.
- W2411403746 countsByYear W24114037462018 @default.
- W2411403746 countsByYear W24114037462019 @default.
- W2411403746 countsByYear W24114037462020 @default.
- W2411403746 countsByYear W24114037462021 @default.
- W2411403746 countsByYear W24114037462022 @default.
- W2411403746 countsByYear W24114037462023 @default.
- W2411403746 crossrefType "journal-article" @default.
- W2411403746 hasAuthorship W2411403746A5020713009 @default.
- W2411403746 hasAuthorship W2411403746A5045723947 @default.
- W2411403746 hasAuthorship W2411403746A5064445924 @default.
- W2411403746 hasAuthorship W2411403746A5070269022 @default.
- W2411403746 hasAuthorship W2411403746A5070902809 @default.
- W2411403746 hasBestOaLocation W24114037461 @default.
- W2411403746 hasConcept C103435993 @default.
- W2411403746 hasConcept C104317684 @default.