Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411418135> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2411418135 endingPage "88" @default.
- W2411418135 startingPage "81" @default.
- W2411418135 abstract "Thirteen forms of glutathione S-transferase were purified from the livers of female rhesus monkeys (Macaque mulatta). Most (74.7%) of the activity in the hepatic cytosol adhered well to the GSH affinity column and could be eluted only with the addition of GSH to the eluting buffer. The predominant isoenzymes (n = 5) in this ‘high-affinity’ fraction had alkaline pI values (greater than 9.0) and contained a subunit with an Mr value of 24,000. All of these isoenzymes had high organic peroxidase activity and, on the basis of amino acid analysis, substrate specificities and affinity for non-substrate ligands, appear to belong to the family of glutathione S-transferases that have been termed alpha [Mannervik, Alin, Guthenberg, Jensson, Tahir, Warholm & Jörnvall (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 7202-7206]. Also within the high-affinity fraction was an isoenzyme with an acidic (5.8) pI value. This acidic isoenzyme was composed of a unique subunit (Mr 23,000). The N-terminal sequence (ten residues) of this acidic enzyme was identical with that of a human form that is referred to as pi. The predominant form of enzyme in the ‘low-affinity’ (eluted from the GSH affinity column with an increase in buffer pH) fraction was a homodimer of a 26,000-Mr subunit. It had an alkaline pI (greater than 9.0) but it lacked organic peroxidase activity. The N-terminal sequence (ten residues) of this enzyme was identical with that of a human enzyme referred to as mu. The substrate specificities and affinity for non-substrate ligands of this monkey enzyme also were similar to those of the human enzyme. In conclusion, the liver cytosol of rhesus monkeys contains a number of glutathione S-transferase isoenzymes that are very similar to the human hepatic enzymes." @default.
- W2411418135 created "2016-06-24" @default.
- W2411418135 creator A5071325908 @default.
- W2411418135 creator A5084795152 @default.
- W2411418135 date "1988-04-01" @default.
- W2411418135 modified "2023-10-06" @default.
- W2411418135 title "Purification and characterization of hepatic glutathione S-transferases of rhesus monkeys. A family of enzymes similar to the human hepatic glutathione <i>S</i>-transferases" @default.
- W2411418135 cites W1493036774 @default.
- W2411418135 cites W1535254030 @default.
- W2411418135 cites W1581414347 @default.
- W2411418135 cites W1588950136 @default.
- W2411418135 cites W1807015004 @default.
- W2411418135 cites W1938073348 @default.
- W2411418135 cites W1967940207 @default.
- W2411418135 cites W1975980695 @default.
- W2411418135 cites W1978793485 @default.
- W2411418135 cites W2002556635 @default.
- W2411418135 cites W2011557023 @default.
- W2411418135 cites W2012320131 @default.
- W2411418135 cites W2013906256 @default.
- W2411418135 cites W2031770876 @default.
- W2411418135 cites W2034261447 @default.
- W2411418135 cites W2037102375 @default.
- W2411418135 cites W2071101822 @default.
- W2411418135 cites W2082497364 @default.
- W2411418135 cites W2090874882 @default.
- W2411418135 cites W2154087820 @default.
- W2411418135 cites W2201884043 @default.
- W2411418135 cites W2218538343 @default.
- W2411418135 cites W2229990068 @default.
- W2411418135 cites W2405810806 @default.
- W2411418135 cites W421722514 @default.
- W2411418135 doi "https://doi.org/10.1042/bj2510081" @default.
- W2411418135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1148966" @default.
- W2411418135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3390162" @default.
- W2411418135 hasPublicationYear "1988" @default.
- W2411418135 type Work @default.
- W2411418135 sameAs 2411418135 @default.
- W2411418135 citedByCount "14" @default.
- W2411418135 crossrefType "journal-article" @default.
- W2411418135 hasAuthorship W2411418135A5071325908 @default.
- W2411418135 hasAuthorship W2411418135A5084795152 @default.
- W2411418135 hasBestOaLocation W24114181352 @default.
- W2411418135 hasConcept C104292427 @default.
- W2411418135 hasConcept C104317684 @default.
- W2411418135 hasConcept C119795356 @default.
- W2411418135 hasConcept C153911025 @default.
- W2411418135 hasConcept C155064970 @default.
- W2411418135 hasConcept C162008176 @default.
- W2411418135 hasConcept C179247698 @default.
- W2411418135 hasConcept C181199279 @default.
- W2411418135 hasConcept C185592680 @default.
- W2411418135 hasConcept C18903297 @default.
- W2411418135 hasConcept C2777289219 @default.
- W2411418135 hasConcept C2778760513 @default.
- W2411418135 hasConcept C538909803 @default.
- W2411418135 hasConcept C55493867 @default.
- W2411418135 hasConcept C86803240 @default.
- W2411418135 hasConcept C98539663 @default.
- W2411418135 hasConceptScore W2411418135C104292427 @default.
- W2411418135 hasConceptScore W2411418135C104317684 @default.
- W2411418135 hasConceptScore W2411418135C119795356 @default.
- W2411418135 hasConceptScore W2411418135C153911025 @default.
- W2411418135 hasConceptScore W2411418135C155064970 @default.
- W2411418135 hasConceptScore W2411418135C162008176 @default.
- W2411418135 hasConceptScore W2411418135C179247698 @default.
- W2411418135 hasConceptScore W2411418135C181199279 @default.
- W2411418135 hasConceptScore W2411418135C185592680 @default.
- W2411418135 hasConceptScore W2411418135C18903297 @default.
- W2411418135 hasConceptScore W2411418135C2777289219 @default.
- W2411418135 hasConceptScore W2411418135C2778760513 @default.
- W2411418135 hasConceptScore W2411418135C538909803 @default.
- W2411418135 hasConceptScore W2411418135C55493867 @default.
- W2411418135 hasConceptScore W2411418135C86803240 @default.
- W2411418135 hasConceptScore W2411418135C98539663 @default.
- W2411418135 hasIssue "1" @default.
- W2411418135 hasLocation W24114181351 @default.
- W2411418135 hasLocation W24114181352 @default.
- W2411418135 hasLocation W24114181353 @default.
- W2411418135 hasLocation W24114181354 @default.
- W2411418135 hasOpenAccess W2411418135 @default.
- W2411418135 hasPrimaryLocation W24114181351 @default.
- W2411418135 hasRelatedWork W1966656764 @default.
- W2411418135 hasRelatedWork W1978176014 @default.
- W2411418135 hasRelatedWork W2024212048 @default.
- W2411418135 hasRelatedWork W2054770995 @default.
- W2411418135 hasRelatedWork W2092017838 @default.
- W2411418135 hasRelatedWork W2355182518 @default.
- W2411418135 hasRelatedWork W2367555336 @default.
- W2411418135 hasRelatedWork W2418435858 @default.
- W2411418135 hasRelatedWork W3144317371 @default.
- W2411418135 hasRelatedWork W43744646 @default.
- W2411418135 hasVolume "251" @default.
- W2411418135 isParatext "false" @default.
- W2411418135 isRetracted "false" @default.
- W2411418135 magId "2411418135" @default.
- W2411418135 workType "article" @default.