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- W2411552435 endingPage "347" @default.
- W2411552435 startingPage "347" @default.
- W2411552435 abstract "Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-κB ligand (RANKL)/receptor activator of the NF-κB (RANK)/osteoprotegerin (OPG) and Wnt-β-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis." @default.
- W2411552435 created "2016-06-24" @default.
- W2411552435 creator A5004770379 @default.
- W2411552435 creator A5034217467 @default.
- W2411552435 creator A5042383355 @default.
- W2411552435 creator A5060302747 @default.
- W2411552435 date "2016-06-07" @default.
- W2411552435 modified "2023-10-12" @default.
- W2411552435 title "The Relationship between Metabolic Syndrome and Osteoporosis: A Review" @default.
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