Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411656456> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2411656456 endingPage "74" @default.
- W2411656456 startingPage "168" @default.
- W2411656456 abstract "To investigate the role of connective tissue growth factor (CTGF) after trabeculectomy associated with wound healing and to identify the role of CTGF in this process.It was a experimental study. Forty-nine rabbits were used and divided into 5 groups: normal eyes without trabeculectomy group (group A), ocular hypertension (OHT) model without trabeculectomy group (group B), OHT model with trabeculectomy group (group C), normal eyes with trabeculectomy group (group D) and normal eyes with sham operation group (group E). Group A and B were as control. CTGF mRNA was detected by RT-PCR using blebs and tissues harvested at day 2, 5, 7, and 14. Three replicates of three blebs per time point in the right eyes were collected. The expression of CTGF protein was detected by immunohistochemistry and inflammatory histopathology was inspected by HE staining using the whole eyeball harvested in the left eyes.Compared to group A and B, the expression of CTGF was significantly increased at day 5 after surgery (F = 19.54, P < 0.05) in group C, D, and E. The expression of CTGF mRNA in group C is significantly higher than that in group D at day 2 and 5 (t = 2.300, 5.140, P < 0.05), while group D is significantly higher than that in group E at day 2, 5, 7, and 14 (t = -2.927, -6.424, -4.176, -4.997, P < 0.05). The expression of CTGF protein in group C is significantly higher than that in group D (t = -7.147, -10.955, -9.900, -6.385, P < 0.05), and group D is higher than that in group E (F = 68.33, P < 0.05) at day 2, 5, 7, and 14, respectively. Inflammatory reaction reached peak at day 5 after surgery in group C, D, and E showing an infiltration of neutrophil, monocytes, macrophages, and the proliferation of fibroblast.Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing. Furthermore, ocular hypertension may be involved in the upregulation of CTGF expression." @default.
- W2411656456 created "2016-06-24" @default.
- W2411656456 creator A5023022658 @default.
- W2411656456 creator A5038965879 @default.
- W2411656456 creator A5044810148 @default.
- W2411656456 creator A5073741770 @default.
- W2411656456 creator A5083729859 @default.
- W2411656456 date "2009-02-01" @default.
- W2411656456 modified "2023-10-02" @default.
- W2411656456 title "[Expression of connective tissue growth factor after trabeculectomy in rabbits]." @default.
- W2411656456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19573340" @default.
- W2411656456 hasPublicationYear "2009" @default.
- W2411656456 type Work @default.
- W2411656456 sameAs 2411656456 @default.
- W2411656456 citedByCount "7" @default.
- W2411656456 countsByYear W24116564562018 @default.
- W2411656456 countsByYear W24116564562019 @default.
- W2411656456 countsByYear W24116564562021 @default.
- W2411656456 countsByYear W24116564562022 @default.
- W2411656456 crossrefType "journal-article" @default.
- W2411656456 hasAuthorship W2411656456A5023022658 @default.
- W2411656456 hasAuthorship W2411656456A5038965879 @default.
- W2411656456 hasAuthorship W2411656456A5044810148 @default.
- W2411656456 hasAuthorship W2411656456A5073741770 @default.
- W2411656456 hasAuthorship W2411656456A5083729859 @default.
- W2411656456 hasConcept C118487528 @default.
- W2411656456 hasConcept C126322002 @default.
- W2411656456 hasConcept C141071460 @default.
- W2411656456 hasConcept C142724271 @default.
- W2411656456 hasConcept C16685009 @default.
- W2411656456 hasConcept C170493617 @default.
- W2411656456 hasConcept C204232928 @default.
- W2411656456 hasConcept C2775960820 @default.
- W2411656456 hasConcept C2777824320 @default.
- W2411656456 hasConcept C2778527774 @default.
- W2411656456 hasConcept C2780269544 @default.
- W2411656456 hasConcept C2780631158 @default.
- W2411656456 hasConcept C2780678043 @default.
- W2411656456 hasConcept C518705261 @default.
- W2411656456 hasConcept C544855455 @default.
- W2411656456 hasConcept C71924100 @default.
- W2411656456 hasConceptScore W2411656456C118487528 @default.
- W2411656456 hasConceptScore W2411656456C126322002 @default.
- W2411656456 hasConceptScore W2411656456C141071460 @default.
- W2411656456 hasConceptScore W2411656456C142724271 @default.
- W2411656456 hasConceptScore W2411656456C16685009 @default.
- W2411656456 hasConceptScore W2411656456C170493617 @default.
- W2411656456 hasConceptScore W2411656456C204232928 @default.
- W2411656456 hasConceptScore W2411656456C2775960820 @default.
- W2411656456 hasConceptScore W2411656456C2777824320 @default.
- W2411656456 hasConceptScore W2411656456C2778527774 @default.
- W2411656456 hasConceptScore W2411656456C2780269544 @default.
- W2411656456 hasConceptScore W2411656456C2780631158 @default.
- W2411656456 hasConceptScore W2411656456C2780678043 @default.
- W2411656456 hasConceptScore W2411656456C518705261 @default.
- W2411656456 hasConceptScore W2411656456C544855455 @default.
- W2411656456 hasConceptScore W2411656456C71924100 @default.
- W2411656456 hasIssue "2" @default.
- W2411656456 hasLocation W24116564561 @default.
- W2411656456 hasOpenAccess W2411656456 @default.
- W2411656456 hasPrimaryLocation W24116564561 @default.
- W2411656456 hasRelatedWork W123239899 @default.
- W2411656456 hasRelatedWork W1989543866 @default.
- W2411656456 hasRelatedWork W2197885532 @default.
- W2411656456 hasRelatedWork W2348231257 @default.
- W2411656456 hasRelatedWork W2354255290 @default.
- W2411656456 hasRelatedWork W2363732507 @default.
- W2411656456 hasRelatedWork W2365757031 @default.
- W2411656456 hasRelatedWork W2384511750 @default.
- W2411656456 hasRelatedWork W2386420889 @default.
- W2411656456 hasRelatedWork W2391264072 @default.
- W2411656456 hasRelatedWork W2391546439 @default.
- W2411656456 hasRelatedWork W2393190292 @default.
- W2411656456 hasRelatedWork W2397834211 @default.
- W2411656456 hasRelatedWork W2409195400 @default.
- W2411656456 hasRelatedWork W2423884529 @default.
- W2411656456 hasRelatedWork W2467476601 @default.
- W2411656456 hasRelatedWork W3029285400 @default.
- W2411656456 hasRelatedWork W3030095531 @default.
- W2411656456 hasRelatedWork W3032435604 @default.
- W2411656456 hasRelatedWork W3032681039 @default.
- W2411656456 hasVolume "45" @default.
- W2411656456 isParatext "false" @default.
- W2411656456 isRetracted "false" @default.
- W2411656456 magId "2411656456" @default.
- W2411656456 workType "article" @default.