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- W2411670259 abstract "Objective Canine model established for tracheal defect reconstruction,to investigate the outcome of tracheal reconstruction with combination of polypropynene and flap. Methods About 3.5 to 4 centimeter cervical trachea was resected and replaced with artificial trachea made from monofilament knitted polypropylene and surgical flap. Covered stent was implanted postoperatively. Survival period and quality of life were recorded, brunchofibroscopy, X-ray films and HE sections were perfomed. Results Six dogs survived well and another two died. The causes of death were respiratory failure in 1 and infection in another. Stenosis of anastomosis in 1 was recorded during survival period. The dogs started drinking and eating on the second postoperative day, no dyspnea was found. The animals were sacrificed at 2, 4, 8 weeks and 6 months after surgery. Soft tissue growth was found in polypropynene net 2 weeks after surgery and more at 4 weeks. The polypropynene net was covered completely with soft tissue at 8 weeks and 6 months postoperatively, the hardness and sustentation degree were enhanced following the growth and fibrosis of soft tissue. The squamous epithelium and columnar epithelium were observed healing well by HE staining method. Conclusions One-stage operative artificial trachea made from monofilament knitted polypropylene which has good histocompatibility and surgical flap is the closer artificial trachea to native trachea. It has a promising prospect in clinical use.Key words: Tracheal diseases; Reconstructive surgical procedures; Models, animal; Prostheses and implants; Polypropylenes; Stents" @default.
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- W2411670259 date "2008-07-01" @default.
- W2411670259 modified "2023-09-23" @default.
- W2411670259 title "An experimental study of polypropylene combined with flap for trachea reconstruction" @default.
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