Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411680894> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2411680894 endingPage "846" @default.
- W2411680894 startingPage "843" @default.
- W2411680894 abstract "Objective To investigate the effects of Hic-5/ARA55 on the growth of the human colorectal cancer cells(Lovo cells)and its mechanism.Method Flow cytometry(FCM)was used to study the cell cycle of Lovo cells(Lovo group),Lovo cells stably transfected with empty vector(Lovo-Vector group)and the Lovo cells stably transfected with vector containing Hic-5/ARA55(Lovo-Hic-5/ARA55group).Western blot assay was used to detect the principal cyclins in the three groups,and Luciferase assay was used to study the mechanism between Hic-5/ARA55 and the only target cyclin. The cells from the three groups were inoculated subcutaneously into 7 nude micef Babl/c nu/nu)respectively to observe the effects of Hic-5/ARA55 on the growth of the cells in vivo.Seven weeks later,the subcutaneous tumors were harvested and weighed.Then immunohistochemistrical assay was used to detect Hic-5/ARA55 and the target cyclin in the tumors.Results The cell cycle was obviously delayed from G0/G1 to S stage in Lovo-Hic-5/ARA55 cells.A significantly higher expression of P27 was found in Lovo-Hic-5/ARA55 cells than in the other two groups.The weight of the subcutaneous tumors of Lovo-Hic-5/ARA55 cells,Lovo cells and Lovo-Vector cells were(0.33±0.23)g,(1.20±0.39)g and(1.30 ±0.49)g,respectively;the tumors of Lovo-Hic-5/ARA55 cells was significantly lighter than those ofthe other two groups(P＜0.05).Hic-5/ARA55 and P27 were beth over-expressed in implanted tumors of Lovo-Hic-5/ARA55 cells,while were both expressed lower or not expressed in the other two groups.And the expressions of Hic-5/ARA55 and P27 were highly positive correlated(r=0.816,P＜0.05).Conclusion Hic-5/ARA55 could inhibit the growth of Lovo cells both in vitro and in vlvo bv up-regulating the transcription of P27.Key words: Colorectal neoplasms; Tumor growth; Hic-5/ARA55; P27" @default.
- W2411680894 created "2016-06-24" @default.
- W2411680894 creator A5003309047 @default.
- W2411680894 creator A5025412257 @default.
- W2411680894 creator A5053578321 @default.
- W2411680894 creator A5060774542 @default.
- W2411680894 creator A5065032876 @default.
- W2411680894 date "2008-06-01" @default.
- W2411680894 modified "2023-10-15" @default.
- W2411680894 title "[Hic-5/ARA55 inhibits the growth of Lovo cells by up-regulating the expression of P27]." @default.
- W2411680894 doi "https://doi.org/10.3321/j.issn:0529-5815.2008.11.013" @default.
- W2411680894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19035221" @default.
- W2411680894 hasPublicationYear "2008" @default.
- W2411680894 type Work @default.
- W2411680894 sameAs 2411680894 @default.
- W2411680894 citedByCount "0" @default.
- W2411680894 crossrefType "journal-article" @default.
- W2411680894 hasAuthorship W2411680894A5003309047 @default.
- W2411680894 hasAuthorship W2411680894A5025412257 @default.
- W2411680894 hasAuthorship W2411680894A5053578321 @default.
- W2411680894 hasAuthorship W2411680894A5060774542 @default.
- W2411680894 hasAuthorship W2411680894A5065032876 @default.
- W2411680894 hasConcept C104317684 @default.
- W2411680894 hasConcept C120089663 @default.
- W2411680894 hasConcept C121608353 @default.
- W2411680894 hasConcept C126322002 @default.
- W2411680894 hasConcept C1491633281 @default.
- W2411680894 hasConcept C153911025 @default.
- W2411680894 hasConcept C199835354 @default.
- W2411680894 hasConcept C2776415932 @default.
- W2411680894 hasConcept C29537977 @default.
- W2411680894 hasConcept C502942594 @default.
- W2411680894 hasConcept C54009773 @default.
- W2411680894 hasConcept C54355233 @default.
- W2411680894 hasConcept C553184892 @default.
- W2411680894 hasConcept C55493867 @default.
- W2411680894 hasConcept C62112901 @default.
- W2411680894 hasConcept C71924100 @default.
- W2411680894 hasConcept C81885089 @default.
- W2411680894 hasConcept C86803240 @default.
- W2411680894 hasConceptScore W2411680894C104317684 @default.
- W2411680894 hasConceptScore W2411680894C120089663 @default.
- W2411680894 hasConceptScore W2411680894C121608353 @default.
- W2411680894 hasConceptScore W2411680894C126322002 @default.
- W2411680894 hasConceptScore W2411680894C1491633281 @default.
- W2411680894 hasConceptScore W2411680894C153911025 @default.
- W2411680894 hasConceptScore W2411680894C199835354 @default.
- W2411680894 hasConceptScore W2411680894C2776415932 @default.
- W2411680894 hasConceptScore W2411680894C29537977 @default.
- W2411680894 hasConceptScore W2411680894C502942594 @default.
- W2411680894 hasConceptScore W2411680894C54009773 @default.
- W2411680894 hasConceptScore W2411680894C54355233 @default.
- W2411680894 hasConceptScore W2411680894C553184892 @default.
- W2411680894 hasConceptScore W2411680894C55493867 @default.
- W2411680894 hasConceptScore W2411680894C62112901 @default.
- W2411680894 hasConceptScore W2411680894C71924100 @default.
- W2411680894 hasConceptScore W2411680894C81885089 @default.
- W2411680894 hasConceptScore W2411680894C86803240 @default.
- W2411680894 hasIssue "11" @default.
- W2411680894 hasLocation W24116808941 @default.
- W2411680894 hasLocation W24116808942 @default.
- W2411680894 hasOpenAccess W2411680894 @default.
- W2411680894 hasPrimaryLocation W24116808941 @default.
- W2411680894 hasRelatedWork W2350565123 @default.
- W2411680894 hasRelatedWork W2356444229 @default.
- W2411680894 hasRelatedWork W2357219769 @default.
- W2411680894 hasRelatedWork W2357553014 @default.
- W2411680894 hasRelatedWork W2359595936 @default.
- W2411680894 hasRelatedWork W2373228689 @default.
- W2411680894 hasRelatedWork W2373470775 @default.
- W2411680894 hasRelatedWork W2390127741 @default.
- W2411680894 hasRelatedWork W2392940903 @default.
- W2411680894 hasRelatedWork W2393958941 @default.
- W2411680894 hasRelatedWork W2396143836 @default.
- W2411680894 hasRelatedWork W2409479742 @default.
- W2411680894 hasRelatedWork W2414611500 @default.
- W2411680894 hasRelatedWork W3029046893 @default.
- W2411680894 hasRelatedWork W3029079829 @default.
- W2411680894 hasRelatedWork W3029285488 @default.
- W2411680894 hasRelatedWork W3029545767 @default.
- W2411680894 hasRelatedWork W3029727849 @default.
- W2411680894 hasRelatedWork W3032170131 @default.
- W2411680894 hasRelatedWork W921557767 @default.
- W2411680894 hasVolume "46" @default.
- W2411680894 isParatext "false" @default.
- W2411680894 isRetracted "false" @default.
- W2411680894 magId "2411680894" @default.
- W2411680894 workType "article" @default.