Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411779740> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2411779740 endingPage "578" @default.
- W2411779740 startingPage "573" @default.
- W2411779740 abstract "Individual variation in drug response is a substantial clinical problem. Research in pharmacogenetics is currently evolving in two directions, firstly to identify genes and gene products associated with certain diseases, which may serve as targets for new drugs, and secondly to identify genes and allelic variants of genes that affect the expected and adverse response to current and future drugs. In that respect drug metabolising enzymes play a key role. A readily and widely available pheno- and/or genotyping service for drug metabolism polymorphisms is currently not established and the clinical relevance has only been shown for a limited number of drugs. The overall pharmacologic effects are typically not monogenic traits, they are a result of an interaction of several genes encoding proteins involved in drug metabolism, disposition, and effects. Each individual represents a unique combination of polymorphic genes that are known to be involved in the metabolism and disposition of medications, in the target structures of drug therapy, and in the pathogenesis of diseases. This will lead to the development of DNA chips for genotyping which will guide the selection and dosing of drug therapy in the future." @default.
- W2411779740 created "2016-06-24" @default.
- W2411779740 creator A5075947367 @default.
- W2411779740 date "2000-09-01" @default.
- W2411779740 modified "2023-09-26" @default.
- W2411779740 title "Clinical relevance of drug metabolism polymorphisms" @default.
- W2411779740 doi "https://doi.org/10.1024/0040-5930.57.9.573" @default.
- W2411779740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11036438" @default.
- W2411779740 hasPublicationYear "2000" @default.
- W2411779740 type Work @default.
- W2411779740 sameAs 2411779740 @default.
- W2411779740 citedByCount "0" @default.
- W2411779740 crossrefType "journal-article" @default.
- W2411779740 hasAuthorship W2411779740A5075947367 @default.
- W2411779740 hasConcept C104317684 @default.
- W2411779740 hasConcept C111472728 @default.
- W2411779740 hasConcept C135763542 @default.
- W2411779740 hasConcept C138885662 @default.
- W2411779740 hasConcept C170734499 @default.
- W2411779740 hasConcept C2780035454 @default.
- W2411779740 hasConcept C31467283 @default.
- W2411779740 hasConcept C54355233 @default.
- W2411779740 hasConcept C55775858 @default.
- W2411779740 hasConcept C60644358 @default.
- W2411779740 hasConcept C70721500 @default.
- W2411779740 hasConcept C71924100 @default.
- W2411779740 hasConcept C86803240 @default.
- W2411779740 hasConcept C89311334 @default.
- W2411779740 hasConcept C89611455 @default.
- W2411779740 hasConcept C98274493 @default.
- W2411779740 hasConceptScore W2411779740C104317684 @default.
- W2411779740 hasConceptScore W2411779740C111472728 @default.
- W2411779740 hasConceptScore W2411779740C135763542 @default.
- W2411779740 hasConceptScore W2411779740C138885662 @default.
- W2411779740 hasConceptScore W2411779740C170734499 @default.
- W2411779740 hasConceptScore W2411779740C2780035454 @default.
- W2411779740 hasConceptScore W2411779740C31467283 @default.
- W2411779740 hasConceptScore W2411779740C54355233 @default.
- W2411779740 hasConceptScore W2411779740C55775858 @default.
- W2411779740 hasConceptScore W2411779740C60644358 @default.
- W2411779740 hasConceptScore W2411779740C70721500 @default.
- W2411779740 hasConceptScore W2411779740C71924100 @default.
- W2411779740 hasConceptScore W2411779740C86803240 @default.
- W2411779740 hasConceptScore W2411779740C89311334 @default.
- W2411779740 hasConceptScore W2411779740C89611455 @default.
- W2411779740 hasConceptScore W2411779740C98274493 @default.
- W2411779740 hasIssue "9" @default.
- W2411779740 hasLocation W24117797401 @default.
- W2411779740 hasLocation W24117797402 @default.
- W2411779740 hasOpenAccess W2411779740 @default.
- W2411779740 hasPrimaryLocation W24117797401 @default.
- W2411779740 hasRelatedWork W1573559951 @default.
- W2411779740 hasRelatedWork W1977781436 @default.
- W2411779740 hasRelatedWork W1985073855 @default.
- W2411779740 hasRelatedWork W1986027462 @default.
- W2411779740 hasRelatedWork W2134348916 @default.
- W2411779740 hasRelatedWork W2337440577 @default.
- W2411779740 hasRelatedWork W2519924859 @default.
- W2411779740 hasRelatedWork W2521506406 @default.
- W2411779740 hasRelatedWork W2557850348 @default.
- W2411779740 hasRelatedWork W3177489481 @default.
- W2411779740 hasVolume "57" @default.
- W2411779740 isParatext "false" @default.
- W2411779740 isRetracted "false" @default.
- W2411779740 magId "2411779740" @default.
- W2411779740 workType "article" @default.