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• W2411923265 abstract "To assess the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pituitary suppression, subsequent ovarian response, and results of in vitro fertilization (IVF) treatments in polycystic ovarian syndrome (PCOS) patients. Randomized prospective study. In vitro fertilization program and endocrinologic institute. Thirty patients with PCOS; 16 received GnRH-a, and 14 did not receive GnRH-a. Ovum pick-up and embryo transfer. Response to GnRH-a test, serum and follicular fluid (FF) hormonal measurements, steroid levels, and aromatse activity in granulosa cell (GC) culture, and results of IVF. Pituitary responsiveness was abolished in all patients 14 days after GnRH-a administration, and early luteinization was prevented. Steroid levels in FF did not differ between the two groups. In GC culture, progesterone (P) levels were higher in patients without the GnRH-a (3,704 ± 1,232 nmol/L versus 2,117 ± 235 nmol/L; P < 0.05) as were androstenedione (A) levels (5.3 ± 1.0 nmol/L versus < 3.5 nmol/L; P < 0.05). However, aromatase activity and IVF results were similar in the two groups. Administration of GnRH-a in patients with PCOS decreases P and A production by the GC cells and prevents early luteinization. It does not affect the IVF results." @default.
• W2411923265 created "2016-06-24" @default.
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• W2411923265 date "1992-02-01" @default.
• W2411923265 modified "2023-10-09" @default.
• W2411923265 title "The effect of gonadotropin-releasing hormone agonist on the ovarian response and in vitro fertilization results in polycystic ovarian syndrome: a prospective study" @default.
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• W2411923265 doi "https://doi.org/10.1016/s0015-0282(16)54847-x" @default.
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• W2411923265 hasPublicationYear "1992" @default.
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