Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411936496> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2411936496 endingPage "9" @default.
- W2411936496 startingPage "145" @default.
- W2411936496 abstract "To identify histopathologic changes of major organs and to correlate clinical symptoms in patients infected by avian influenza H5N1.Autopsy study was performed in two patients died of avian influenza HSN1 infection, following conventional protocols and strict safety procedures. Tissue samples from all major organs of two cases and lung samples of one case were collected and fixed in 4% formaldehyde. Histopathologic changes were evaluated by light microscope.Diffuse alveolar damage (DAD) of the lung was seen in both cases. Lesions at various stages of development were seen involving different areas of the lung. At the early stages, the lungs exhibited exudative changes, including capillary congestion, necrosis of alveolar epithelial cells, and intra-alveolar edema. Hyaline membranes were prominent and diffusely distributed along alveoli. In the middle-late stages of the disease, the lungs exhibited proliferative and fibrotic changes, including proliferation of pneumocytes and bronchial epithelium, fibrosis of the interstitium and alveolar spaces. Lung biopsy tissue of one case showed DAD and interstitial fibrosis in a background of bronchiectasis. Lymph nodes and spleens showed quantity reduction of lymphocytes and active hemophagocytosis. Other changes in major organs included interstitial carditis in one case and acute renal tubular necrosis in one case. In one case, the brain showed edema with cytoplasmic eosinophilia, loss of structure, axon welling and focal necrosis around ventricle. Multiple foci of trophoblastic necrosis with dystrophic calcification were observed in placenta of one pregnant patient. Acute necrotizing deciduitis was found focally. Sections of fetal lung showed edema and scattered interstitial neutrophils were consistent with acute interstitial pneumonitis.The respiratory tract is the major target of avian influenza A H5N1 virus infection. The changes of DAD in the lungs resulted in hypoxia, leading to multiple organ failure and death." @default.
- W2411936496 created "2016-06-24" @default.
- W2411936496 creator A5005602911 @default.
- W2411936496 creator A5006760859 @default.
- W2411936496 creator A5013038112 @default.
- W2411936496 creator A5013938837 @default.
- W2411936496 creator A5041471384 @default.
- W2411936496 creator A5045445998 @default.
- W2411936496 creator A5045782024 @default.
- W2411936496 creator A5049255635 @default.
- W2411936496 creator A5073387841 @default.
- W2411936496 date "2008-03-01" @default.
- W2411936496 modified "2023-09-28" @default.
- W2411936496 title "[Histopathologic study of avian influenza H5N1 infection in humans]." @default.
- W2411936496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18788588" @default.
- W2411936496 hasPublicationYear "2008" @default.
- W2411936496 type Work @default.
- W2411936496 sameAs 2411936496 @default.
- W2411936496 citedByCount "4" @default.
- W2411936496 countsByYear W24119364962012 @default.
- W2411936496 countsByYear W24119364962015 @default.
- W2411936496 countsByYear W24119364962020 @default.
- W2411936496 countsByYear W24119364962022 @default.
- W2411936496 crossrefType "journal-article" @default.
- W2411936496 hasAuthorship W2411936496A5005602911 @default.
- W2411936496 hasAuthorship W2411936496A5006760859 @default.
- W2411936496 hasAuthorship W2411936496A5013038112 @default.
- W2411936496 hasAuthorship W2411936496A5013938837 @default.
- W2411936496 hasAuthorship W2411936496A5041471384 @default.
- W2411936496 hasAuthorship W2411936496A5045445998 @default.
- W2411936496 hasAuthorship W2411936496A5045782024 @default.
- W2411936496 hasAuthorship W2411936496A5049255635 @default.
- W2411936496 hasAuthorship W2411936496A5073387841 @default.
- W2411936496 hasConcept C118494813 @default.
- W2411936496 hasConcept C126322002 @default.
- W2411936496 hasConcept C142724271 @default.
- W2411936496 hasConcept C2777714996 @default.
- W2411936496 hasConcept C2780559512 @default.
- W2411936496 hasConcept C2780886150 @default.
- W2411936496 hasConcept C2909621147 @default.
- W2411936496 hasConcept C503630168 @default.
- W2411936496 hasConcept C71924100 @default.
- W2411936496 hasConcept C9418649 @default.
- W2411936496 hasConceptScore W2411936496C118494813 @default.
- W2411936496 hasConceptScore W2411936496C126322002 @default.
- W2411936496 hasConceptScore W2411936496C142724271 @default.
- W2411936496 hasConceptScore W2411936496C2777714996 @default.
- W2411936496 hasConceptScore W2411936496C2780559512 @default.
- W2411936496 hasConceptScore W2411936496C2780886150 @default.
- W2411936496 hasConceptScore W2411936496C2909621147 @default.
- W2411936496 hasConceptScore W2411936496C503630168 @default.
- W2411936496 hasConceptScore W2411936496C71924100 @default.
- W2411936496 hasConceptScore W2411936496C9418649 @default.
- W2411936496 hasIssue "3" @default.
- W2411936496 hasLocation W24119364961 @default.
- W2411936496 hasOpenAccess W2411936496 @default.
- W2411936496 hasPrimaryLocation W24119364961 @default.
- W2411936496 hasRelatedWork W14943430 @default.
- W2411936496 hasRelatedWork W197465979 @default.
- W2411936496 hasRelatedWork W1984807710 @default.
- W2411936496 hasRelatedWork W2034777643 @default.
- W2411936496 hasRelatedWork W2041768503 @default.
- W2411936496 hasRelatedWork W2083738263 @default.
- W2411936496 hasRelatedWork W2084162279 @default.
- W2411936496 hasRelatedWork W2158118659 @default.
- W2411936496 hasRelatedWork W2169865372 @default.
- W2411936496 hasRelatedWork W2324061613 @default.
- W2411936496 hasRelatedWork W2361955106 @default.
- W2411936496 hasRelatedWork W2366285195 @default.
- W2411936496 hasRelatedWork W2375677212 @default.
- W2411936496 hasRelatedWork W2386957335 @default.
- W2411936496 hasRelatedWork W2392453982 @default.
- W2411936496 hasRelatedWork W2411961663 @default.
- W2411936496 hasRelatedWork W2413602034 @default.
- W2411936496 hasRelatedWork W2415604181 @default.
- W2411936496 hasRelatedWork W2467669096 @default.
- W2411936496 hasRelatedWork W3124847188 @default.
- W2411936496 hasVolume "37" @default.
- W2411936496 isParatext "false" @default.
- W2411936496 isRetracted "false" @default.
- W2411936496 magId "2411936496" @default.
- W2411936496 workType "article" @default.