Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411961886> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2411961886 endingPage "9" @default.
- W2411961886 startingPage "263" @default.
- W2411961886 abstract "The bcr gene rearrangement resulting from the Philadelphia translocation is diagnostic of chronic myelogenous leukemia (CML) and is considered the hallmark of this myeloproliferative disorder (MPD) at the molecular level. The other MPDs, essential thrombocythemia (ET), polycythemia vera (PV), agnogenic myeloid metaplasia (AMM), and unclassified MPD, share morphologic features with CML, making the diagnosis difficult in cases with considerable morphologic overlap. In such cases, molecular analysis becomes essential for accurate diagnosis. We report results of bcr analysis by Southern hybridization in 37 patients with MPDs other than CML: ET (20 cases), PV (seven cases). unclassified MPD (nine cases), as well as in one case of chronic myelomonocytic leukemia (CMML). bcr negativity ruled out CML in 36 cases, confirming the morphologic diagnosis. In one case diagnosed as ET. bcr gene rearrangement was diagnostic of CML. The correct diagnosis made possible a different therapeutic approach in this young patient and resulted in cure after allogeneic bone marrow transplantation. The existence of such cases makes the use of molecular analysis essential in the evaluation of MPDs, even when the morphologic features do not unequivocally support the diagnosis of CML, as in this patient." @default.
- W2411961886 created "2016-06-24" @default.
- W2411961886 creator A5005171408 @default.
- W2411961886 creator A5016241508 @default.
- W2411961886 creator A5033832833 @default.
- W2411961886 creator A5047821488 @default.
- W2411961886 creator A5065906402 @default.
- W2411961886 date "1996-01-01" @default.
- W2411961886 modified "2023-09-23" @default.
- W2411961886 title "bcr gene rearrangement analysis in myeloproliferative disorders other than chronic myelogenous leukemia." @default.
- W2411961886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8818385" @default.
- W2411961886 hasPublicationYear "1996" @default.
- W2411961886 type Work @default.
- W2411961886 sameAs 2411961886 @default.
- W2411961886 citedByCount "0" @default.
- W2411961886 crossrefType "journal-article" @default.
- W2411961886 hasAuthorship W2411961886A5005171408 @default.
- W2411961886 hasAuthorship W2411961886A5016241508 @default.
- W2411961886 hasAuthorship W2411961886A5033832833 @default.
- W2411961886 hasAuthorship W2411961886A5047821488 @default.
- W2411961886 hasAuthorship W2411961886A5065906402 @default.
- W2411961886 hasConcept C104317684 @default.
- W2411961886 hasConcept C126322002 @default.
- W2411961886 hasConcept C142724271 @default.
- W2411961886 hasConcept C170493617 @default.
- W2411961886 hasConcept C2776960273 @default.
- W2411961886 hasConcept C2777928532 @default.
- W2411961886 hasConcept C2778461978 @default.
- W2411961886 hasConcept C2778729363 @default.
- W2411961886 hasConcept C2778837598 @default.
- W2411961886 hasConcept C2779282312 @default.
- W2411961886 hasConcept C2780007613 @default.
- W2411961886 hasConcept C2780076729 @default.
- W2411961886 hasConcept C2780817109 @default.
- W2411961886 hasConcept C2781057849 @default.
- W2411961886 hasConcept C2910274570 @default.
- W2411961886 hasConcept C2992511266 @default.
- W2411961886 hasConcept C43907098 @default.
- W2411961886 hasConcept C502942594 @default.
- W2411961886 hasConcept C54355233 @default.
- W2411961886 hasConcept C71924100 @default.
- W2411961886 hasConcept C86803240 @default.
- W2411961886 hasConceptScore W2411961886C104317684 @default.
- W2411961886 hasConceptScore W2411961886C126322002 @default.
- W2411961886 hasConceptScore W2411961886C142724271 @default.
- W2411961886 hasConceptScore W2411961886C170493617 @default.
- W2411961886 hasConceptScore W2411961886C2776960273 @default.
- W2411961886 hasConceptScore W2411961886C2777928532 @default.
- W2411961886 hasConceptScore W2411961886C2778461978 @default.
- W2411961886 hasConceptScore W2411961886C2778729363 @default.
- W2411961886 hasConceptScore W2411961886C2778837598 @default.
- W2411961886 hasConceptScore W2411961886C2779282312 @default.
- W2411961886 hasConceptScore W2411961886C2780007613 @default.
- W2411961886 hasConceptScore W2411961886C2780076729 @default.
- W2411961886 hasConceptScore W2411961886C2780817109 @default.
- W2411961886 hasConceptScore W2411961886C2781057849 @default.
- W2411961886 hasConceptScore W2411961886C2910274570 @default.
- W2411961886 hasConceptScore W2411961886C2992511266 @default.
- W2411961886 hasConceptScore W2411961886C43907098 @default.
- W2411961886 hasConceptScore W2411961886C502942594 @default.
- W2411961886 hasConceptScore W2411961886C54355233 @default.
- W2411961886 hasConceptScore W2411961886C71924100 @default.
- W2411961886 hasConceptScore W2411961886C86803240 @default.
- W2411961886 hasIssue "4" @default.
- W2411961886 hasLocation W24119618861 @default.
- W2411961886 hasOpenAccess W2411961886 @default.
- W2411961886 hasPrimaryLocation W24119618861 @default.
- W2411961886 hasRelatedWork W171149585 @default.
- W2411961886 hasRelatedWork W2070839556 @default.
- W2411961886 hasRelatedWork W2088778255 @default.
- W2411961886 hasRelatedWork W2146505525 @default.
- W2411961886 hasRelatedWork W2318231374 @default.
- W2411961886 hasRelatedWork W2411961886 @default.
- W2411961886 hasRelatedWork W2966361730 @default.
- W2411961886 hasRelatedWork W3179720695 @default.
- W2411961886 hasRelatedWork W4210486064 @default.
- W2411961886 hasRelatedWork W953077886 @default.
- W2411961886 hasVolume "20" @default.
- W2411961886 isParatext "false" @default.
- W2411961886 isRetracted "false" @default.
- W2411961886 magId "2411961886" @default.
- W2411961886 workType "article" @default.