Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411969488> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2411969488 endingPage "23" @default.
- W2411969488 startingPage "19" @default.
- W2411969488 abstract "This study describes bone metabolism in children withjuvenile idiopathic arthritis (JIA), association between disturbances of bone metabolism with inflammatory activity, juvenile arthritis disease course and therapy in 198 children. Low bone mineral density (BMD) for chronological age was detected by dual-energy X-ray absorptiometry of lumbar spine L1-L4 (densitometer Hologic QDR 4500C, with pediatric reference database) than Z -score < -2 SD in 36 children (18,2%), in 18 girls (15,5%) and in 18 boys (21,9%). Girls with low BMD received glucocorticoids (GCS) in 66,7 % cases, and girls with normal BMD received it in 26,5% cases (р=0,002). Girls with low BMD had lower height, weight, earlier age of disease onset and higher clinical and laboratory parameters of arthritis activity. Girls with low BMD had higher osteocalcin and tendency to decreased parathyroid hormone levels compared to the girls with normal BMD. Children who received GCS had specific stereotypic changes: boys had significantly lower bone mineral density and total Ca and girls had significantly lower bone mineral content and BMD (g/cm2 and Z-score), total Са, non-organic phosphate and total alkaline phosphatase activity. Patients with systemic arthritis had significantly lower mineralization and bone metabolism turnover compared to children with oligoarticular and polyarticular JIA subtypes. Independent predictors of skeletal mineralization were age onset f JIA (р<0,0001), duration of the disease (p<0,0001), hemoglobin level (р=0,004), total calcium level (р=0,024), a2-globulins level (р=0,046). Independent predictors of low BMD were physician’s assessment VAS (р=0,024), C-reactive protein (р=0,04), inorganic phosphate (р=0,05). Systemic glucocorticoids exposure elevated the risk of low BMD for chronological age realization in JIA patients (OR=1,96, 95%CI=0,76-5,05). Enhanced risk of low BMD was in polyarthicular (OR=2,53, 95%CI=0,66-9,65) and systemic JIA (OR=3,16, 95%CI=0,73-13,76). Thus, parameters of inflammation have negative influence on bone metabolism velocity, linear growth and accordingly bone mineralization. Described factors explain heterogeneity of mineralization disorders." @default.
- W2411969488 created "2016-06-24" @default.
- W2411969488 creator A5023942119 @default.
- W2411969488 creator A5034361337 @default.
- W2411969488 creator A5037055735 @default.
- W2411969488 creator A5040222551 @default.
- W2411969488 creator A5040639563 @default.
- W2411969488 creator A5053525968 @default.
- W2411969488 date "2011-12-15" @default.
- W2411969488 modified "2023-09-27" @default.
- W2411969488 title "KOSTNAYa MASSA I KOSTNYY METABOLIZM U DETEY S YuVENIL'NYM IDIOPATIChESKIM ARTRITOM" @default.
- W2411969488 cites W1982760683 @default.
- W2411969488 cites W2029277544 @default.
- W2411969488 cites W2104099956 @default.
- W2411969488 cites W2156732134 @default.
- W2411969488 doi "https://doi.org/10.14341/osteo2011319-23" @default.
- W2411969488 hasPublicationYear "2011" @default.
- W2411969488 type Work @default.
- W2411969488 sameAs 2411969488 @default.
- W2411969488 citedByCount "0" @default.
- W2411969488 crossrefType "journal-article" @default.
- W2411969488 hasAuthorship W2411969488A5023942119 @default.
- W2411969488 hasAuthorship W2411969488A5034361337 @default.
- W2411969488 hasAuthorship W2411969488A5037055735 @default.
- W2411969488 hasAuthorship W2411969488A5040222551 @default.
- W2411969488 hasAuthorship W2411969488A5040639563 @default.
- W2411969488 hasAuthorship W2411969488A5053525968 @default.
- W2411969488 hasBestOaLocation W24119694881 @default.
- W2411969488 hasConcept C126322002 @default.
- W2411969488 hasConcept C131075544 @default.
- W2411969488 hasConcept C134018914 @default.
- W2411969488 hasConcept C160160445 @default.
- W2411969488 hasConcept C170033053 @default.
- W2411969488 hasConcept C181199279 @default.
- W2411969488 hasConcept C185592680 @default.
- W2411969488 hasConcept C2776541429 @default.
- W2411969488 hasConcept C2776886416 @default.
- W2411969488 hasConcept C2777077863 @default.
- W2411969488 hasConcept C55493867 @default.
- W2411969488 hasConcept C71924100 @default.
- W2411969488 hasConceptScore W2411969488C126322002 @default.
- W2411969488 hasConceptScore W2411969488C131075544 @default.
- W2411969488 hasConceptScore W2411969488C134018914 @default.
- W2411969488 hasConceptScore W2411969488C160160445 @default.
- W2411969488 hasConceptScore W2411969488C170033053 @default.
- W2411969488 hasConceptScore W2411969488C181199279 @default.
- W2411969488 hasConceptScore W2411969488C185592680 @default.
- W2411969488 hasConceptScore W2411969488C2776541429 @default.
- W2411969488 hasConceptScore W2411969488C2776886416 @default.
- W2411969488 hasConceptScore W2411969488C2777077863 @default.
- W2411969488 hasConceptScore W2411969488C55493867 @default.
- W2411969488 hasConceptScore W2411969488C71924100 @default.
- W2411969488 hasIssue "3" @default.
- W2411969488 hasLocation W24119694881 @default.
- W2411969488 hasOpenAccess W2411969488 @default.
- W2411969488 hasPrimaryLocation W24119694881 @default.
- W2411969488 hasRelatedWork W2022695623 @default.
- W2411969488 hasRelatedWork W2024155257 @default.
- W2411969488 hasRelatedWork W2036148628 @default.
- W2411969488 hasRelatedWork W2041938128 @default.
- W2411969488 hasRelatedWork W2073151133 @default.
- W2411969488 hasRelatedWork W2081570904 @default.
- W2411969488 hasRelatedWork W2128714854 @default.
- W2411969488 hasRelatedWork W2133403819 @default.
- W2411969488 hasRelatedWork W2155593667 @default.
- W2411969488 hasRelatedWork W2160818938 @default.
- W2411969488 hasVolume "14" @default.
- W2411969488 isParatext "false" @default.
- W2411969488 isRetracted "false" @default.
- W2411969488 magId "2411969488" @default.
- W2411969488 workType "article" @default.