Matches in SemOpenAlex for { <https://semopenalex.org/work/W2411993857> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2411993857 endingPage "E237" @default.
- W2411993857 startingPage "E233" @default.
- W2411993857 abstract "We measured in vitro release of luteinizing hormone (LH) in the presence of 1.5 mM extracellular calcium, with and without LH-releasing hormone (LHRH; 10(-10) to 10(-7) M) or the ionophore A23187 (10(-7) to 10(-4) M), in primary cultures of anterior pituitary cells from intact mature (6 mo) and old (24 mo) male and intact and ovariectomized mature and old female Wistar rats. Base-line as well as LHRH- and A23187-mediated LH secretion was decreased from cells of old rats. However, exposure to A23187 led to a nearly twofold greater augmentation of LH release from cells of old rats, thus decreasing the apparent age-related LH secretory deficit by approximately one-half. We then measured LHRH-mediated (10(-8) M) vs. A23187-mediated (10(-4) M) LH release with and without extracellular calcium (0.08-1.5 mM). For cells from both mature and old rats, there was a similar calcium dependency for A23187- and LHRH-mediated LH release, with optimal LH secretion at 1.0-1.5 mM extracellular calcium concentrations. Again, both LHRH- and A23187-stimulated LH release was significantly lower and exposure to A23187 led to a greater increase in LH release from cells of old rats. Taken together with similar findings in other systems, these data suggest that the in vitro LH secretory defect of pituitary cells from old rats results in part from one or more defects in calcium mobilization and that such alterations may be a widespread manifestation of aging." @default.
- W2411993857 created "2016-06-24" @default.
- W2411993857 creator A5043431442 @default.
- W2411993857 creator A5068665691 @default.
- W2411993857 creator A5090431787 @default.
- W2411993857 date "1987-09-01" @default.
- W2411993857 modified "2023-10-13" @default.
- W2411993857 title "Ionophore A23187 partially reverses LH secretory defect of pituitary cells from old rats" @default.
- W2411993857 cites W1606395976 @default.
- W2411993857 cites W1977779461 @default.
- W2411993857 cites W1980234060 @default.
- W2411993857 cites W1982449770 @default.
- W2411993857 cites W2011891202 @default.
- W2411993857 cites W2018989166 @default.
- W2411993857 cites W2019833955 @default.
- W2411993857 cites W2026252099 @default.
- W2411993857 cites W2038168669 @default.
- W2411993857 cites W2100662381 @default.
- W2411993857 cites W2103390240 @default.
- W2411993857 cites W2152903088 @default.
- W2411993857 cites W2154645918 @default.
- W2411993857 cites W2417047908 @default.
- W2411993857 doi "https://doi.org/10.1152/ajpendo.1987.253.3.e233" @default.
- W2411993857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3115112" @default.
- W2411993857 hasPublicationYear "1987" @default.
- W2411993857 type Work @default.
- W2411993857 sameAs 2411993857 @default.
- W2411993857 citedByCount "10" @default.
- W2411993857 crossrefType "journal-article" @default.
- W2411993857 hasAuthorship W2411993857A5043431442 @default.
- W2411993857 hasAuthorship W2411993857A5068665691 @default.
- W2411993857 hasAuthorship W2411993857A5090431787 @default.
- W2411993857 hasConcept C126322002 @default.
- W2411993857 hasConcept C134018914 @default.
- W2411993857 hasConcept C185592680 @default.
- W2411993857 hasConcept C2777658017 @default.
- W2411993857 hasConcept C2778575703 @default.
- W2411993857 hasConcept C2779014961 @default.
- W2411993857 hasConcept C2779029589 @default.
- W2411993857 hasConcept C28406088 @default.
- W2411993857 hasConcept C49039625 @default.
- W2411993857 hasConcept C519063684 @default.
- W2411993857 hasConcept C55493867 @default.
- W2411993857 hasConcept C71315377 @default.
- W2411993857 hasConcept C71924100 @default.
- W2411993857 hasConcept C8264082 @default.
- W2411993857 hasConcept C86803240 @default.
- W2411993857 hasConceptScore W2411993857C126322002 @default.
- W2411993857 hasConceptScore W2411993857C134018914 @default.
- W2411993857 hasConceptScore W2411993857C185592680 @default.
- W2411993857 hasConceptScore W2411993857C2777658017 @default.
- W2411993857 hasConceptScore W2411993857C2778575703 @default.
- W2411993857 hasConceptScore W2411993857C2779014961 @default.
- W2411993857 hasConceptScore W2411993857C2779029589 @default.
- W2411993857 hasConceptScore W2411993857C28406088 @default.
- W2411993857 hasConceptScore W2411993857C49039625 @default.
- W2411993857 hasConceptScore W2411993857C519063684 @default.
- W2411993857 hasConceptScore W2411993857C55493867 @default.
- W2411993857 hasConceptScore W2411993857C71315377 @default.
- W2411993857 hasConceptScore W2411993857C71924100 @default.
- W2411993857 hasConceptScore W2411993857C8264082 @default.
- W2411993857 hasConceptScore W2411993857C86803240 @default.
- W2411993857 hasIssue "3" @default.
- W2411993857 hasLocation W24119938571 @default.
- W2411993857 hasLocation W24119938572 @default.
- W2411993857 hasOpenAccess W2411993857 @default.
- W2411993857 hasPrimaryLocation W24119938571 @default.
- W2411993857 hasRelatedWork W1972504921 @default.
- W2411993857 hasRelatedWork W1981336606 @default.
- W2411993857 hasRelatedWork W2000882911 @default.
- W2411993857 hasRelatedWork W2013119480 @default.
- W2411993857 hasRelatedWork W2013753219 @default.
- W2411993857 hasRelatedWork W2034020161 @default.
- W2411993857 hasRelatedWork W2089507710 @default.
- W2411993857 hasRelatedWork W2146788134 @default.
- W2411993857 hasRelatedWork W2420936620 @default.
- W2411993857 hasRelatedWork W4238226706 @default.
- W2411993857 hasVolume "253" @default.
- W2411993857 isParatext "false" @default.
- W2411993857 isRetracted "false" @default.
- W2411993857 magId "2411993857" @default.
- W2411993857 workType "article" @default.