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- W2412099860 endingPage "1179" @default.
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- W2412099860 abstract "Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic manipulation of fundamental disease processes." @default.
- W2412099860 created "2016-06-24" @default.
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- W2412099860 date "2016-05-31" @default.
- W2412099860 modified "2023-10-16" @default.
- W2412099860 title "Modeling psychiatric disorders: from genomic findings to cellular phenotypes" @default.
- W2412099860 cites W1490681631 @default.
- W2412099860 cites W1553983967 @default.
- W2412099860 cites W1555966838 @default.
- W2412099860 cites W155621635 @default.
- W2412099860 cites W1571164133 @default.
- W2412099860 cites W1598521203 @default.
- W2412099860 cites W1635914561 @default.
- W2412099860 cites W1638444713 @default.
- W2412099860 cites W1671213273 @default.
- W2412099860 cites W1768523798 @default.
- W2412099860 cites W1814150115 @default.
- W2412099860 cites W1855058198 @default.
- W2412099860 cites W1924860558 @default.
- W2412099860 cites W1961529886 @default.
- W2412099860 cites W1963673462 @default.
- W2412099860 cites W1964287957 @default.
- W2412099860 cites W1965718692 @default.
- W2412099860 cites W1966171594 @default.
- W2412099860 cites W1966212340 @default.
- W2412099860 cites W1967786563 @default.
- W2412099860 cites W1967801453 @default.
- W2412099860 cites W1968461255 @default.
- W2412099860 cites W1969205004 @default.
- W2412099860 cites W1969300914 @default.
- W2412099860 cites W1971637333 @default.
- W2412099860 cites W1976555450 @default.
- W2412099860 cites W1976730655 @default.
- W2412099860 cites W1980404098 @default.
- W2412099860 cites W1981026552 @default.
- W2412099860 cites W1981794681 @default.
- W2412099860 cites W1981920636 @default.
- W2412099860 cites W1984512942 @default.
- W2412099860 cites W1987942611 @default.
- W2412099860 cites W1987964841 @default.
- W2412099860 cites W198899238 @default.
- W2412099860 cites W1989151396 @default.
- W2412099860 cites W1989700831 @default.
- W2412099860 cites W1991107962 @default.
- W2412099860 cites W1991857137 @default.
- W2412099860 cites W1993030331 @default.
- W2412099860 cites W1995792348 @default.
- W2412099860 cites W1999024554 @default.
- W2412099860 cites W2002747593 @default.
- W2412099860 cites W2003253047 @default.
- W2412099860 cites W2003357682 @default.
- W2412099860 cites W2008485310 @default.
- W2412099860 cites W2010420011 @default.
- W2412099860 cites W2014444260 @default.
- W2412099860 cites W2016717347 @default.
- W2412099860 cites W2017826413 @default.
- W2412099860 cites W2018286352 @default.
- W2412099860 cites W2018560153 @default.
- W2412099860 cites W2019465651 @default.
- W2412099860 cites W2020914828 @default.
- W2412099860 cites W2022825972 @default.
- W2412099860 cites W2023962370 @default.
- W2412099860 cites W2025430305 @default.
- W2412099860 cites W2028033268 @default.
- W2412099860 cites W2030286643 @default.
- W2412099860 cites W2031240433 @default.
- W2412099860 cites W2033877733 @default.
- W2412099860 cites W2036030316 @default.
- W2412099860 cites W2040988960 @default.
- W2412099860 cites W2041652776 @default.
- W2412099860 cites W2044025778 @default.
- W2412099860 cites W2045227722 @default.
- W2412099860 cites W2047626399 @default.
- W2412099860 cites W2048834720 @default.
- W2412099860 cites W2050788543 @default.
- W2412099860 cites W2052047776 @default.
- W2412099860 cites W2055834662 @default.
- W2412099860 cites W2057431271 @default.
- W2412099860 cites W2060271985 @default.
- W2412099860 cites W2060476427 @default.
- W2412099860 cites W2060801754 @default.
- W2412099860 cites W2061921368 @default.
- W2412099860 cites W2063601228 @default.
- W2412099860 cites W2066650190 @default.
- W2412099860 cites W2069721797 @default.
- W2412099860 cites W2071984705 @default.
- W2412099860 cites W2072310044 @default.
- W2412099860 cites W2080240579 @default.