FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412120034> ?p ?o ?g. }

• W2412120034 endingPage "780" @default.
• W2412120034 startingPage "771" @default.
• W2412120034 abstract "1. Activation by H+ and by Ca2+ of 2-oxoglutarate dehydrogenase extracted from mitochondria of normal or acidotic rat kidney is described. This effect, first shown for the enzyme from heart by McCormack & Denton [Biochem. J. (1979) 180, 533—544], is of a regulatory importance in kidney, in which organ, in contrast with heart, increased flux occurs during acute acidosis. 2. In renal-cortical tubules, 2-oxoglutarate concentration fell within 1 min of decreasing the pH and rose again 1—3 min after increasing the pH of the medium. The extent of the decrease in 2-oxoglutarate was directly related to the decrease in pH. A similar fall in the oxoglutarate concentration in the whole perfused kidney was noted within 5 min of inducing acidosis. 3. In tubules, the rates of gluconeogenesis and ammoniagenesis from 1 mM-glutamine were increased by 64 and 33% respectively on decreasing pH to 7.0, the increase in rates being proportional to the fall in pH between 7.4 and 7.0. 4. The increased rates of renal ammoniagenesis and gluconeogenesis seen in acute acidosis in vitro can be accounted for by the increased activity of 2-oxoglutarate dehydrogenase and the tissue concentrations of 2-oxoglutarate when calculated from the Km determined at normal and acidotic pH. 5. The decrease in 2-oxoglutarate concentration seen in acute acidosis implies a fall in intramitochondrial pH in kidney, and is the result of two phenomena, accelerated disposal via 2-oxoglutarate dehydrogenase and maintenance of near equilibrium of glutamate dehydrogenase." @default.
• W2412120034 created "2016-06-24" @default.
• W2412120034 creator A5033596055 @default.
• W2412120034 creator A5068034123 @default.
• W2412120034 date "1980-09-15" @default.
• W2412120034 modified "2023-09-27" @default.
• W2412120034 title "Activation of oxoglutarate dehydrogenase in the kidney in response to acute acidosis" @default.
• W2412120034 cites W1277647379 @default.
• W2412120034 cites W135762540 @default.
• W2412120034 cites W1580746914 @default.
• W2412120034 cites W1595805083 @default.
• W2412120034 cites W164845398 @default.
• W2412120034 cites W1801184284 @default.
• W2412120034 cites W1852782425 @default.
• W2412120034 cites W1954669653 @default.
• W2412120034 cites W1962657470 @default.
• W2412120034 cites W1970496480 @default.
• W2412120034 cites W1980736469 @default.
• W2412120034 cites W1993592613 @default.
• W2412120034 cites W2072015313 @default.
• W2412120034 cites W2088328699 @default.
• W2412120034 cites W2094356110 @default.
• W2412120034 cites W2148056713 @default.
• W2412120034 cites W2152576575 @default.
• W2412120034 cites W2329581294 @default.
• W2412120034 cites W2334265510 @default.
• W2412120034 cites W2337676142 @default.
• W2412120034 cites W2339285763 @default.
• W2412120034 cites W2344416073 @default.
• W2412120034 cites W2364682303 @default.
• W2412120034 cites W2397865436 @default.
• W2412120034 cites W2415325545 @default.
• W2412120034 cites W2418914200 @default.
• W2412120034 cites W2440553874 @default.
• W2412120034 cites W2466951156 @default.
• W2412120034 cites W89068342 @default.
• W2412120034 doi "https://doi.org/10.1042/bj1900771" @default.
• W2412120034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1162158" @default.
• W2412120034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7470078" @default.
• W2412120034 hasPublicationYear "1980" @default.
• W2412120034 type Work @default.
• W2412120034 sameAs 2412120034 @default.
• W2412120034 citedByCount "75" @default.
• W2412120034 countsByYear W24121200342012 @default.
• W2412120034 countsByYear W24121200342013 @default.
• W2412120034 countsByYear W24121200342014 @default.
• W2412120034 countsByYear W24121200342015 @default.
• W2412120034 countsByYear W24121200342016 @default.
• W2412120034 countsByYear W24121200342017 @default.
• W2412120034 countsByYear W24121200342018 @default.
• W2412120034 countsByYear W24121200342019 @default.
• W2412120034 countsByYear W24121200342020 @default.
• W2412120034 crossrefType "journal-article" @default.
• W2412120034 hasAuthorship W2412120034A5033596055 @default.
• W2412120034 hasAuthorship W2412120034A5068034123 @default.
• W2412120034 hasBestOaLocation W24121200342 @default.
• W2412120034 hasConcept C126322002 @default.
• W2412120034 hasConcept C134018914 @default.
• W2412120034 hasConcept C170493617 @default.
• W2412120034 hasConcept C181199279 @default.
• W2412120034 hasConcept C185592680 @default.
• W2412120034 hasConcept C20904676 @default.
• W2412120034 hasConcept C2776317432 @default.
• W2412120034 hasConcept C2777202666 @default.
• W2412120034 hasConcept C2778553927 @default.
• W2412120034 hasConcept C2779246250 @default.
• W2412120034 hasConcept C2779349466 @default.
• W2412120034 hasConcept C2780091579 @default.
• W2412120034 hasConcept C515207424 @default.
• W2412120034 hasConcept C55493867 @default.
• W2412120034 hasConcept C61174792 @default.
• W2412120034 hasConcept C62231903 @default.
• W2412120034 hasConcept C71924100 @default.
• W2412120034 hasConcept C86803240 @default.
• W2412120034 hasConcept C88099638 @default.
• W2412120034 hasConceptScore W2412120034C126322002 @default.
• W2412120034 hasConceptScore W2412120034C134018914 @default.
• W2412120034 hasConceptScore W2412120034C170493617 @default.
• W2412120034 hasConceptScore W2412120034C181199279 @default.
• W2412120034 hasConceptScore W2412120034C185592680 @default.
• W2412120034 hasConceptScore W2412120034C20904676 @default.
• W2412120034 hasConceptScore W2412120034C2776317432 @default.
• W2412120034 hasConceptScore W2412120034C2777202666 @default.
• W2412120034 hasConceptScore W2412120034C2778553927 @default.
• W2412120034 hasConceptScore W2412120034C2779246250 @default.
• W2412120034 hasConceptScore W2412120034C2779349466 @default.
• W2412120034 hasConceptScore W2412120034C2780091579 @default.
• W2412120034 hasConceptScore W2412120034C515207424 @default.
• W2412120034 hasConceptScore W2412120034C55493867 @default.
• W2412120034 hasConceptScore W2412120034C61174792 @default.
• W2412120034 hasConceptScore W2412120034C62231903 @default.
• W2412120034 hasConceptScore W2412120034C71924100 @default.
• W2412120034 hasConceptScore W2412120034C86803240 @default.
• W2412120034 hasConceptScore W2412120034C88099638 @default.
• W2412120034 hasIssue "3" @default.
• W2412120034 hasLocation W24121200341 @default.
• W2412120034 hasLocation W24121200342 @default.
• W2412120034 hasLocation W24121200343 @default.

• next