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- W2412171493 abstract "Objective To study the effects of different positive end-expiratory pressure (PEEP) levels on the heart function of patients undergoing mechanical ventilation (MV) with echocardiography. Methods Thirty-six critical patients with respiratory failure undergoing MVwere divided into two groups according to the cardiac index (CI). The left heart function was measured with echocardiography at different PEEP levels (0, 4, 7, 10, 14 cm H2O, 1cm H2O = 0. 098 kPa). Results In the normal cardiac function group (CI≥2. 0 L · min-1 · m-2, n=17), an increase in PEEP had no significant effects on left ventricular systolic function [left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV),cardiac output (CO), ejection fraction (EF)]. The increase in PEEP had no significant effect on left ventricular diastolic function [mitral early diastolic filling velocity (E), late diastolic filling velocity (A), the ratio of E/A, early diastolic velocity (Ve), late diastolic velocity (Va), the ratio of Ve/Va, left ventricular end-diastolic pressure (LVEDP)]. In the poor cardiac function group (CI＜ 2. 0 L · min-1 · m-2, n = 19),when PEEP was increased to 10 cm H2O and 14 cm H2O, compared with PEEP 0, left ventricular systolic function indexes including LVFSV (ml: 21.2±1.2 vs. 18. 2±1.4 as 10 cm H2O) was significantly higher,i.e. LVEDV (ml: 42. 6±2. 4, 40. 1±1.9 vs. 44. 5±3. 5), CO (L: 2. 3±0. 6, 2. 1±0. 7 vs. 2. 6±0. 7), EF (0. 40±0. 02, 0. 39±0. 02 vs. 0. 420. 02) were decreased (all P＜0. 05); left ventricular diastolic function indexes including A (cm/s: 88.5±15.2, 93.2±18.7 vs. 76.0±9.0), Va (cm/s: 14.3±4.5, 15.8±5.3vs. 12.0±1.2), LVEDP [mmHg (1 mm Hg=0.133 kPa):15.3±2.0, 16.9±2.8 vs. 10.7±2.5] were significantly higher; E (cm/s: 73. 6±15.4, 63.2±16.4 vs. 83.1±20.1), the ratio of E/A (0. 83±0. 10,0.68±0.20 vs. 1.10±0.20), Ve (cm/s: 11.7±1.8, 10.4±2.0 vs. 13.8±2.8), the ratio of Ve/Va (0. 8±0. 1, 0. 6±0. 2 vs. 1.2±0. 2) were decreased (all P＜0. 05). Conclusion Under the same condition of MV, change in PEEP levels (0 - 14 cm H2O) do not produce any obvious effect in the normal cardiac function group, on the other hand when PEEP≥10 cm H2O left heart function is significantly dowered in the poor cardiac function group. Optimial PEEP may improve the cardiac function.Key words: Echocardiography; Mechanical ventilation; Positive end-expiratory pressure; Heart function" @default.
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- W2412171493 date "2011-04-01" @default.
- W2412171493 modified "2023-09-23" @default.
- W2412171493 title "Study of the effects of mechanical ventilation on the heart function of patients with echocardiography" @default.
- W2412171493 doi "https://doi.org/10.3760/cma.j.issn.1003-0603.2011.04.014" @default.
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