FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412185629> ?p ?o ?g. }

• W2412185629 endingPage "9" @default.
• W2412185629 startingPage "S77" @default.
• W2412185629 abstract "Newer anti-proliferative drugs Deoxyspergualin is a novel anti-proliferative drug derived from bacillus laterosporus that suppresses lymphocyte and macrophage function and impairs neutrophil production (1). Studies in refractory ANCA-associated vasculitis and crescentic glomerulonephritis have demonstrated useful efficacy and in a murine model of spontaneous vasculitis, deoxyspergualin was superior to mycophenolate mofetil and as effective as cyclophosphamide in the control of vasculitis (2-5). A larger, multi-centre study of deoxyspergualin in 46 patients with refractory Wegenerʼs granulomatosis has recently been completed (6). This study found a response rate of 90% with almost half of patients reaching a sustained full remission accompanied by significant reductions in prednisolone requirement. The improvement in disease activity was maintained after stopping deoxyspergualin during treatment with azathioprine. Deoxyspergualin has the potential to replace cyclophosphamide for the induction of remission in vasculitis without exposing patients to the fertility and malignancy risks of cyclophosphamide. Reversible leukopenia was frequent with deoxyspergualin and required close monitoring of blood counts. Mycophenolate mofetil and leflunomide are licensed for the treatment of solid organ transplantation and rheumatoid arthritis respectively and are also under evaluation in vasculitis. Small studies in refractory vasculitis have reported a variable response to mycophenolate and a retrospective review in 53 patients with relapsing ANCA associated vasculitis found useful disease responses in over 50% of patients but dosing was limited by toxicity and subsequent relapse rates were high (7-9). A randomised comparison of leflunomide to methotrexate for remission maintenance after cyclophosphamide induction was stopped early due to an excess of major flares in the methotrexate group (10). However, adverse events were more frequent in the leflunomide limb and the differences between methotrexate and leflunomide may, in part, have related to dosing. This study supports the use of leflunomide as an alternative drug for remission maintenance. Two studies are investigating the roles of mycophenolate mofetil for remission induction and maintenance therapy in vasculitis (11)." @default.
• W2412185629 created "2016-06-24" @default.
• W2412185629 creator A5070674274 @default.
• W2412185629 date "2007-04-13" @default.
• W2412185629 modified "2023-09-23" @default.
• W2412185629 title "Part 3: Newer therapies for ANCA-associated vasculitis." @default.
• W2412185629 cites W1585554327 @default.
• W2412185629 cites W1975528665 @default.
• W2412185629 cites W1990008470 @default.
• W2412185629 cites W2001987212 @default.
• W2412185629 cites W2004194066 @default.
• W2412185629 cites W2021553913 @default.
• W2412185629 cites W2022495067 @default.
• W2412185629 cites W2040211602 @default.
• W2412185629 cites W2058825081 @default.
• W2412185629 cites W2094089611 @default.
• W2412185629 cites W2095708018 @default.
• W2412185629 cites W2097043422 @default.
• W2412185629 cites W2099096560 @default.
• W2412185629 cites W2106777223 @default.
• W2412185629 cites W2109774040 @default.
• W2412185629 cites W2121430040 @default.
• W2412185629 cites W2124009165 @default.
• W2412185629 cites W2125346357 @default.
• W2412185629 cites W2127764751 @default.
• W2412185629 cites W2141356919 @default.
• W2412185629 cites W2150622301 @default.
• W2412185629 cites W2151033853 @default.
• W2412185629 cites W2441959468 @default.
• W2412185629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428377" @default.
• W2412185629 hasPublicationYear "2007" @default.
• W2412185629 type Work @default.
• W2412185629 sameAs 2412185629 @default.
• W2412185629 citedByCount "1" @default.
• W2412185629 crossrefType "journal-article" @default.
• W2412185629 hasAuthorship W2412185629A5070674274 @default.
• W2412185629 hasConcept C126322002 @default.
• W2412185629 hasConcept C203014093 @default.
• W2412185629 hasConcept C2775905006 @default.
• W2412185629 hasConcept C2776015282 @default.
• W2412185629 hasConcept C2776694085 @default.
• W2412185629 hasConcept C2776715498 @default.
• W2412185629 hasConcept C2776755627 @default.
• W2412185629 hasConcept C2776760755 @default.
• W2412185629 hasConcept C2777575956 @default.
• W2412185629 hasConcept C2779134260 @default.
• W2412185629 hasConcept C2780252810 @default.
• W2412185629 hasConcept C2781059491 @default.
• W2412185629 hasConcept C71924100 @default.
• W2412185629 hasConcept C90924648 @default.
• W2412185629 hasConceptScore W2412185629C126322002 @default.
• W2412185629 hasConceptScore W2412185629C203014093 @default.
• W2412185629 hasConceptScore W2412185629C2775905006 @default.
• W2412185629 hasConceptScore W2412185629C2776015282 @default.
• W2412185629 hasConceptScore W2412185629C2776694085 @default.
• W2412185629 hasConceptScore W2412185629C2776715498 @default.
• W2412185629 hasConceptScore W2412185629C2776755627 @default.
• W2412185629 hasConceptScore W2412185629C2776760755 @default.
• W2412185629 hasConceptScore W2412185629C2777575956 @default.
• W2412185629 hasConceptScore W2412185629C2779134260 @default.
• W2412185629 hasConceptScore W2412185629C2780252810 @default.
• W2412185629 hasConceptScore W2412185629C2781059491 @default.
• W2412185629 hasConceptScore W2412185629C71924100 @default.
• W2412185629 hasConceptScore W2412185629C90924648 @default.
• W2412185629 hasIssue "1 Suppl 44" @default.
• W2412185629 hasLocation W24121856291 @default.
• W2412185629 hasOpenAccess W2412185629 @default.
• W2412185629 hasPrimaryLocation W24121856291 @default.
• W2412185629 hasRelatedWork W1973070554 @default.
• W2412185629 hasRelatedWork W2026866979 @default.
• W2412185629 hasRelatedWork W2050761780 @default.
• W2412185629 hasRelatedWork W2113973485 @default.
• W2412185629 hasRelatedWork W2121428289 @default.
• W2412185629 hasVolume "25" @default.
• W2412185629 isParatext "false" @default.
• W2412185629 isRetracted "false" @default.
• W2412185629 magId "2412185629" @default.
• W2412185629 workType "article" @default.