Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412250418> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2412250418 endingPage "45" @default.
- W2412250418 startingPage "37" @default.
- W2412250418 abstract "The effects of itopride hydrochloride, a new drug used to regulate motility in the gastrointestinal tract, on the delayed rectifier K+ current (I(K)) and the L-type Ca2+ current (I(Ca)) were evaluated in guinea-pig ventricular myocytes at concentrations of 1, 10 and 100 microM to determine whether the drug has a proarrhythmic effect through blockade of I(K). Itopride did not affect I(K) at concentrations of 100 microM or less, and no significant effects of 1, 10 or 100 microM itopride were observed on the inward rectifier K+ current (I(K1)) responsible for the resting potential and final repolarization phase of the action potential. We next investigated the effects of itopride on L-type Ca2+ current (I(Ca)). Significant inhibition of I(Ca) was observed at itopride concentrations greater than 10 microM. These results suggested that itopride hydrochloride has an inhibitory effect on I(Ca) at concentrations much higher than those in clinical use." @default.
- W2412250418 created "2016-06-24" @default.
- W2412250418 creator A5007672008 @default.
- W2412250418 creator A5008008608 @default.
- W2412250418 creator A5009861886 @default.
- W2412250418 creator A5014417299 @default.
- W2412250418 creator A5048787856 @default.
- W2412250418 creator A5049196605 @default.
- W2412250418 date "1999-01-01" @default.
- W2412250418 modified "2023-09-23" @default.
- W2412250418 title "Effects of itopride hydrochloride on the delayed rectifier K+ and L-type CA2+ currents in guinea-pig ventricular myocytes." @default.
- W2412250418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11127807" @default.
- W2412250418 hasPublicationYear "1999" @default.
- W2412250418 type Work @default.
- W2412250418 sameAs 2412250418 @default.
- W2412250418 citedByCount "1" @default.
- W2412250418 countsByYear W24122504182017 @default.
- W2412250418 crossrefType "journal-article" @default.
- W2412250418 hasAuthorship W2412250418A5007672008 @default.
- W2412250418 hasAuthorship W2412250418A5008008608 @default.
- W2412250418 hasAuthorship W2412250418A5009861886 @default.
- W2412250418 hasAuthorship W2412250418A5014417299 @default.
- W2412250418 hasAuthorship W2412250418A5048787856 @default.
- W2412250418 hasAuthorship W2412250418A5049196605 @default.
- W2412250418 hasConcept C126322002 @default.
- W2412250418 hasConcept C134018914 @default.
- W2412250418 hasConcept C146403970 @default.
- W2412250418 hasConcept C170493617 @default.
- W2412250418 hasConcept C185263204 @default.
- W2412250418 hasConcept C185592680 @default.
- W2412250418 hasConcept C2778815084 @default.
- W2412250418 hasConcept C50254741 @default.
- W2412250418 hasConcept C55493867 @default.
- W2412250418 hasConcept C71924100 @default.
- W2412250418 hasConcept C94924445 @default.
- W2412250418 hasConcept C98274493 @default.
- W2412250418 hasConceptScore W2412250418C126322002 @default.
- W2412250418 hasConceptScore W2412250418C134018914 @default.
- W2412250418 hasConceptScore W2412250418C146403970 @default.
- W2412250418 hasConceptScore W2412250418C170493617 @default.
- W2412250418 hasConceptScore W2412250418C185263204 @default.
- W2412250418 hasConceptScore W2412250418C185592680 @default.
- W2412250418 hasConceptScore W2412250418C2778815084 @default.
- W2412250418 hasConceptScore W2412250418C50254741 @default.
- W2412250418 hasConceptScore W2412250418C55493867 @default.
- W2412250418 hasConceptScore W2412250418C71924100 @default.
- W2412250418 hasConceptScore W2412250418C94924445 @default.
- W2412250418 hasConceptScore W2412250418C98274493 @default.
- W2412250418 hasIssue "1-2" @default.
- W2412250418 hasLocation W24122504181 @default.
- W2412250418 hasOpenAccess W2412250418 @default.
- W2412250418 hasPrimaryLocation W24122504181 @default.
- W2412250418 hasRelatedWork W1561915708 @default.
- W2412250418 hasRelatedWork W1978325487 @default.
- W2412250418 hasRelatedWork W2022618164 @default.
- W2412250418 hasRelatedWork W2033827516 @default.
- W2412250418 hasRelatedWork W2041168023 @default.
- W2412250418 hasRelatedWork W2074981430 @default.
- W2412250418 hasRelatedWork W2079398847 @default.
- W2412250418 hasRelatedWork W2298443277 @default.
- W2412250418 hasRelatedWork W3146698821 @default.
- W2412250418 hasRelatedWork W2026029490 @default.
- W2412250418 hasVolume "106" @default.
- W2412250418 isParatext "false" @default.
- W2412250418 isRetracted "false" @default.
- W2412250418 magId "2412250418" @default.
- W2412250418 workType "article" @default.