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- W2412259730 abstract "Crohn’s disease (CD) is one of the major type of inflammatory bowel diseases(IBD) that affects the gastrointestinal tract. There were a lot of susceptible genes beingpublished based on different population studies as well as meta-analysis projects. In thisstudy, we aimed to investigate the association of some genes, NOD1, CXCL16, STAT6,TLR4, ATG16L1 and IRGM had been found with association to the disease on non-Malaysian population. Overall, 85 CD DNA samples and 250 control healthy sampleswere collected from University Malaya Medical Center (UMMC). DNA were extractedand analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or TaqMan assay amplification. Results obtained showed that NOD1(PG/A=0.5179, ORG/A=1.135, 95% CIG/A=0.786 – 1.637), STAT6 (PA/G=0.531,ORA/G=0.884, 95% CIA/G=0.621 - 1.258) and IRGM variants (Prs4958847=0.154,Prs11747270=0.09359, Prs72553867=0.8844) had no association with CD. CXCL16(PC/T=0.04819, ORC/T=1.431, 95% CIC/T=1.009 - 2.031), TLR4 (PC/T=0.007,ORC/T=0.437, 95% CIC/T=0.242 - 0.789) and ATG16L1 variant rs2241880(PA/G=0.01462, ORA/G=0.645, 95% CIA/G =0.454 - 0.917) were found to be associatedwith Malaysian patients. For stratified analysis, TLR4 (P=0.0002399) and ATG16L1rs2241880 variant (P=0.03619) were significantly associated with Malay whileATG16L1 variant 6754677 (P=6.3x10-3) was associated with Indian patients. Inconclusion, CXCL16, TLR4 and ATG16L1 but not NOD1, STAT6 and IRGM were foundto have strong association with CD in the Malaysian population." @default.
- W2412259730 created "2016-06-24" @default.
- W2412259730 creator A5061469061 @default.
- W2412259730 date "2014-01-01" @default.
- W2412259730 modified "2023-09-27" @default.
- W2412259730 title "Genetic polymorphisms of the NOD1,CXCL16,STAT6,TLR4, ATG16LI and IRGM Genesin Malaysia patients with crohn's disease / Ng Jin Guan" @default.
- W2412259730 hasPublicationYear "2014" @default.
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