Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412265046> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2412265046 endingPage "44" @default.
- W2412265046 startingPage "134" @default.
- W2412265046 abstract "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are amongst the most abundant of the heterocyclic aromatic amines formed during the cooking of beef. Both compounds are genotoxic and carcinogenic in rodents. These effects are manifested only after activation of the amines by P450. Human liver is very active at converting these amines to mutagenic products. Studies in vitro have established that, for both amines, mutagenicity with human liver microsomes is entirely via the N-hydroxylamine, essentially the only oxidation product of either amine. Both N-hydroxylation and mutagenicity of the amines can be almost completely inhibited by furafylline, a potent and highly selective inhibitor of CYP1A2 in man. These data, together with the work of others, show that the N-hydroxylation and hence the mutagenicity of both MeIQx and PhIP in man is catalyzed almost exclusively by CYP1A2. Liver from cynomolgus monkeys, unlike that from humans and marmosets, is very poor at activating MeIQx or PhIP to mutagenic products. Studies with anti-peptide antibodies of defined specificity revealed that this is due to the absence of CYP1A2, suggesting that this species should not be used to assess the possible risk posed to man by these amines. The marmoset would be a better species for this purpose." @default.
- W2412265046 created "2016-06-24" @default.
- W2412265046 creator A5000085780 @default.
- W2412265046 creator A5016842652 @default.
- W2412265046 creator A5032058390 @default.
- W2412265046 creator A5034780971 @default.
- W2412265046 creator A5050026019 @default.
- W2412265046 creator A5071905126 @default.
- W2412265046 creator A5080413964 @default.
- W2412265046 creator A5082661034 @default.
- W2412265046 creator A5084555780 @default.
- W2412265046 date "1995-01-01" @default.
- W2412265046 modified "2023-09-23" @default.
- W2412265046 title "Enzymatic studies of the activation of heterocyclic food mutagens in man." @default.
- W2412265046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8844804" @default.
- W2412265046 hasPublicationYear "1995" @default.
- W2412265046 type Work @default.
- W2412265046 sameAs 2412265046 @default.
- W2412265046 citedByCount "5" @default.
- W2412265046 countsByYear W24122650462013 @default.
- W2412265046 crossrefType "journal-article" @default.
- W2412265046 hasAuthorship W2412265046A5000085780 @default.
- W2412265046 hasAuthorship W2412265046A5016842652 @default.
- W2412265046 hasAuthorship W2412265046A5032058390 @default.
- W2412265046 hasAuthorship W2412265046A5034780971 @default.
- W2412265046 hasAuthorship W2412265046A5050026019 @default.
- W2412265046 hasAuthorship W2412265046A5071905126 @default.
- W2412265046 hasAuthorship W2412265046A5080413964 @default.
- W2412265046 hasAuthorship W2412265046A5082661034 @default.
- W2412265046 hasAuthorship W2412265046A5084555780 @default.
- W2412265046 hasConcept C114246631 @default.
- W2412265046 hasConcept C178790620 @default.
- W2412265046 hasConcept C181199279 @default.
- W2412265046 hasConcept C185592680 @default.
- W2412265046 hasConcept C2775999725 @default.
- W2412265046 hasConcept C2776639595 @default.
- W2412265046 hasConcept C2777278644 @default.
- W2412265046 hasConcept C2778818824 @default.
- W2412265046 hasConcept C2779043668 @default.
- W2412265046 hasConcept C2779485729 @default.
- W2412265046 hasConcept C2780362310 @default.
- W2412265046 hasConcept C2781109383 @default.
- W2412265046 hasConcept C55493867 @default.
- W2412265046 hasConcept C86745063 @default.
- W2412265046 hasConcept C87644729 @default.
- W2412265046 hasConceptScore W2412265046C114246631 @default.
- W2412265046 hasConceptScore W2412265046C178790620 @default.
- W2412265046 hasConceptScore W2412265046C181199279 @default.
- W2412265046 hasConceptScore W2412265046C185592680 @default.
- W2412265046 hasConceptScore W2412265046C2775999725 @default.
- W2412265046 hasConceptScore W2412265046C2776639595 @default.
- W2412265046 hasConceptScore W2412265046C2777278644 @default.
- W2412265046 hasConceptScore W2412265046C2778818824 @default.
- W2412265046 hasConceptScore W2412265046C2779043668 @default.
- W2412265046 hasConceptScore W2412265046C2779485729 @default.
- W2412265046 hasConceptScore W2412265046C2780362310 @default.
- W2412265046 hasConceptScore W2412265046C2781109383 @default.
- W2412265046 hasConceptScore W2412265046C55493867 @default.
- W2412265046 hasConceptScore W2412265046C86745063 @default.
- W2412265046 hasConceptScore W2412265046C87644729 @default.
- W2412265046 hasLocation W24122650461 @default.
- W2412265046 hasOpenAccess W2412265046 @default.
- W2412265046 hasPrimaryLocation W24122650461 @default.
- W2412265046 hasRelatedWork W1982593239 @default.
- W2412265046 hasRelatedWork W2003844448 @default.
- W2412265046 hasRelatedWork W2011388067 @default.
- W2412265046 hasRelatedWork W2012145166 @default.
- W2412265046 hasRelatedWork W2030797357 @default.
- W2412265046 hasRelatedWork W2077904894 @default.
- W2412265046 hasRelatedWork W2286986007 @default.
- W2412265046 hasRelatedWork W2332000201 @default.
- W2412265046 hasRelatedWork W2412265046 @default.
- W2412265046 hasRelatedWork W2416414649 @default.
- W2412265046 hasVolume "23" @default.
- W2412265046 isParatext "false" @default.
- W2412265046 isRetracted "false" @default.
- W2412265046 magId "2412265046" @default.
- W2412265046 workType "article" @default.