Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412290398> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2412290398 endingPage "69" @default.
- W2412290398 startingPage "959" @default.
- W2412290398 abstract "The multistage nature of carcinogenesis observed in a variety of systems has been linked experimentally to the sequential activation and subsequent cooperation of oncogene proteins. Cellular transformation resulting from cooperative interactions between activated oncogenes has been described previously for cultured primary cells and certain established cell lines. Our laboratory is using the mouse embryonic cell line C3H10T1/2 to investigate cooperative transformation mediated by the activated human H-ras gene and several nuclear oncogenes from both viral and cellular sources. Oncogene cooperation in C3H10T1/2 is marked by an increase in focus number and an alteration in focus morphology. Although ras cooperates with myc and fos oncogenes to transform C3H10T1/2 fibroblasts, cooperative transformation is not observed in cells similarly co-transfected with the H-ras and E1A oncogenes. This result appears to be due to a growth inhibitory effect of the EIA gene product on C3H10T1/2 cells. The observed cooperation between the H-ras and MC29 viral gag-myc oncogenes has been used along with site-directed mutagenesis of the gag-myc gene to identify two structural regions within the gag-myc protein that mediate ras/myc cooperativity. In addition, the gag-myc mutants generated for these cooperation studies have been used to map the nuclear localization signal of the gag-myc protein and relate the proper cellular location of the protein to its activity in several transformation assays." @default.
- W2412290398 created "2016-06-24" @default.
- W2412290398 creator A5000790375 @default.
- W2412290398 creator A5017267891 @default.
- W2412290398 creator A5041244405 @default.
- W2412290398 creator A5061049318 @default.
- W2412290398 creator A5081980487 @default.
- W2412290398 date "1988-09-01" @default.
- W2412290398 modified "2023-09-23" @default.
- W2412290398 title "Cooperation of oncogenes in the multistep transformation of established fibroblasts in culture." @default.
- W2412290398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2845855" @default.
- W2412290398 hasPublicationYear "1988" @default.
- W2412290398 type Work @default.
- W2412290398 sameAs 2412290398 @default.
- W2412290398 citedByCount "6" @default.
- W2412290398 countsByYear W24122903982022 @default.
- W2412290398 crossrefType "journal-article" @default.
- W2412290398 hasAuthorship W2412290398A5000790375 @default.
- W2412290398 hasAuthorship W2412290398A5017267891 @default.
- W2412290398 hasAuthorship W2412290398A5041244405 @default.
- W2412290398 hasAuthorship W2412290398A5061049318 @default.
- W2412290398 hasAuthorship W2412290398A5081980487 @default.
- W2412290398 hasConcept C104317684 @default.
- W2412290398 hasConcept C143065580 @default.
- W2412290398 hasConcept C150194340 @default.
- W2412290398 hasConcept C153911025 @default.
- W2412290398 hasConcept C16318435 @default.
- W2412290398 hasConcept C165864922 @default.
- W2412290398 hasConcept C195286587 @default.
- W2412290398 hasConcept C204241405 @default.
- W2412290398 hasConcept C2781018059 @default.
- W2412290398 hasConcept C2909762590 @default.
- W2412290398 hasConcept C2910786375 @default.
- W2412290398 hasConcept C29537977 @default.
- W2412290398 hasConcept C501734568 @default.
- W2412290398 hasConcept C54009773 @default.
- W2412290398 hasConcept C54355233 @default.
- W2412290398 hasConcept C555283112 @default.
- W2412290398 hasConcept C81885089 @default.
- W2412290398 hasConcept C86803240 @default.
- W2412290398 hasConcept C95444343 @default.
- W2412290398 hasConceptScore W2412290398C104317684 @default.
- W2412290398 hasConceptScore W2412290398C143065580 @default.
- W2412290398 hasConceptScore W2412290398C150194340 @default.
- W2412290398 hasConceptScore W2412290398C153911025 @default.
- W2412290398 hasConceptScore W2412290398C16318435 @default.
- W2412290398 hasConceptScore W2412290398C165864922 @default.
- W2412290398 hasConceptScore W2412290398C195286587 @default.
- W2412290398 hasConceptScore W2412290398C204241405 @default.
- W2412290398 hasConceptScore W2412290398C2781018059 @default.
- W2412290398 hasConceptScore W2412290398C2909762590 @default.
- W2412290398 hasConceptScore W2412290398C2910786375 @default.
- W2412290398 hasConceptScore W2412290398C29537977 @default.
- W2412290398 hasConceptScore W2412290398C501734568 @default.
- W2412290398 hasConceptScore W2412290398C54009773 @default.
- W2412290398 hasConceptScore W2412290398C54355233 @default.
- W2412290398 hasConceptScore W2412290398C555283112 @default.
- W2412290398 hasConceptScore W2412290398C81885089 @default.
- W2412290398 hasConceptScore W2412290398C86803240 @default.
- W2412290398 hasConceptScore W2412290398C95444343 @default.
- W2412290398 hasIssue "5A" @default.
- W2412290398 hasLocation W24122903981 @default.
- W2412290398 hasOpenAccess W2412290398 @default.
- W2412290398 hasPrimaryLocation W24122903981 @default.
- W2412290398 hasRelatedWork W1500227984 @default.
- W2412290398 hasRelatedWork W1513108917 @default.
- W2412290398 hasRelatedWork W1525023012 @default.
- W2412290398 hasRelatedWork W1562024901 @default.
- W2412290398 hasRelatedWork W2147466517 @default.
- W2412290398 hasRelatedWork W2347120132 @default.
- W2412290398 hasRelatedWork W2379610755 @default.
- W2412290398 hasRelatedWork W2387406543 @default.
- W2412290398 hasRelatedWork W2412290398 @default.
- W2412290398 hasRelatedWork W97075190 @default.
- W2412290398 hasVolume "8" @default.
- W2412290398 isParatext "false" @default.
- W2412290398 isRetracted "false" @default.
- W2412290398 magId "2412290398" @default.
- W2412290398 workType "article" @default.