Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412296800> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2412296800 endingPage "F441" @default.
- W2412296800 startingPage "F436" @default.
- W2412296800 abstract "The effect of molecular charge of proteins on proximal tubular reabsorption was evaluated in the rat. Native and two cationized forms of albumin, native and anionized lysozyme, and native and anionized cytochrome c were iodinated with 125I. The different forms of each type of protein were alternately microinfused into the same site of proximal convoluted tubules in vivo. Tubular reabsorption was determined as the difference between the amounts of TCA-precipitable radioactivity infused and recovered in the urine. At low concentration of albumin 5 times more cationized than anionic albumin and 2.7 times more cationic than anionized lysozyme were reabsorbed by the proximal tubule. At two of four concentrations, proximal tubular uptake of cationic cytochrome c exceeded that of anionized cytochrome c. Uptake of cationic cytochrome c exceeded that of cationic lysozyme; however, the difference in uptake between native cationic and anionized species of the two proteins was much greater for lysozyme than for cytochrome c. The data reveal that a higher isoelectric point significantly enhances proximal tubular reabsorption of albumin, lysozyme, and cytochrome c and that proteins with similar molecular weight and isoelectric point are not necessarily reabsorbed to the same degree. This suggests that in addition to total molecular charge the molecular configuration and/or distribution of electrical charges on teh protein surface determine protein binding by the luminal membrane and subsequent endocytosis by the proximal tubule." @default.
- W2412296800 created "2016-06-24" @default.
- W2412296800 creator A5033005270 @default.
- W2412296800 creator A5063752377 @default.
- W2412296800 creator A5081845933 @default.
- W2412296800 date "1983-04-01" @default.
- W2412296800 modified "2023-09-26" @default.
- W2412296800 title "Renal tubular uptake of protein: effect of molecular charge" @default.
- W2412296800 doi "https://doi.org/10.1152/ajprenal.1983.244.4.f436" @default.
- W2412296800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6301286" @default.
- W2412296800 hasPublicationYear "1983" @default.
- W2412296800 type Work @default.
- W2412296800 sameAs 2412296800 @default.
- W2412296800 citedByCount "60" @default.
- W2412296800 countsByYear W24122968002012 @default.
- W2412296800 countsByYear W24122968002014 @default.
- W2412296800 countsByYear W24122968002016 @default.
- W2412296800 countsByYear W24122968002017 @default.
- W2412296800 countsByYear W24122968002018 @default.
- W2412296800 countsByYear W24122968002019 @default.
- W2412296800 countsByYear W24122968002020 @default.
- W2412296800 countsByYear W24122968002022 @default.
- W2412296800 countsByYear W24122968002023 @default.
- W2412296800 crossrefType "journal-article" @default.
- W2412296800 hasAuthorship W2412296800A5033005270 @default.
- W2412296800 hasAuthorship W2412296800A5063752377 @default.
- W2412296800 hasAuthorship W2412296800A5081845933 @default.
- W2412296800 hasConcept C12554922 @default.
- W2412296800 hasConcept C178790620 @default.
- W2412296800 hasConcept C181199279 @default.
- W2412296800 hasConcept C183882617 @default.
- W2412296800 hasConcept C185592680 @default.
- W2412296800 hasConcept C2776125364 @default.
- W2412296800 hasConcept C2776966407 @default.
- W2412296800 hasConcept C2780768313 @default.
- W2412296800 hasConcept C28859421 @default.
- W2412296800 hasConcept C29311851 @default.
- W2412296800 hasConcept C537181965 @default.
- W2412296800 hasConcept C55493867 @default.
- W2412296800 hasConcept C56906281 @default.
- W2412296800 hasConcept C86803240 @default.
- W2412296800 hasConcept C96294017 @default.
- W2412296800 hasConceptScore W2412296800C12554922 @default.
- W2412296800 hasConceptScore W2412296800C178790620 @default.
- W2412296800 hasConceptScore W2412296800C181199279 @default.
- W2412296800 hasConceptScore W2412296800C183882617 @default.
- W2412296800 hasConceptScore W2412296800C185592680 @default.
- W2412296800 hasConceptScore W2412296800C2776125364 @default.
- W2412296800 hasConceptScore W2412296800C2776966407 @default.
- W2412296800 hasConceptScore W2412296800C2780768313 @default.
- W2412296800 hasConceptScore W2412296800C28859421 @default.
- W2412296800 hasConceptScore W2412296800C29311851 @default.
- W2412296800 hasConceptScore W2412296800C537181965 @default.
- W2412296800 hasConceptScore W2412296800C55493867 @default.
- W2412296800 hasConceptScore W2412296800C56906281 @default.
- W2412296800 hasConceptScore W2412296800C86803240 @default.
- W2412296800 hasConceptScore W2412296800C96294017 @default.
- W2412296800 hasIssue "4" @default.
- W2412296800 hasLocation W24122968001 @default.
- W2412296800 hasLocation W24122968002 @default.
- W2412296800 hasOpenAccess W2412296800 @default.
- W2412296800 hasPrimaryLocation W24122968001 @default.
- W2412296800 hasRelatedWork W1981066863 @default.
- W2412296800 hasRelatedWork W1985029012 @default.
- W2412296800 hasRelatedWork W1991868321 @default.
- W2412296800 hasRelatedWork W1993871478 @default.
- W2412296800 hasRelatedWork W2012173471 @default.
- W2412296800 hasRelatedWork W2044105907 @default.
- W2412296800 hasRelatedWork W2065109063 @default.
- W2412296800 hasRelatedWork W2412296800 @default.
- W2412296800 hasRelatedWork W2416450332 @default.
- W2412296800 hasRelatedWork W4236452009 @default.
- W2412296800 hasVolume "244" @default.
- W2412296800 isParatext "false" @default.
- W2412296800 isRetracted "false" @default.
- W2412296800 magId "2412296800" @default.
- W2412296800 workType "article" @default.