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- W2412347745 abstract "Abstract Glutamine formation is the major pathway of ammonia detoxication in tissues other than the liver. When a competitive inhibitor of the glutamine synthetase reaction, methionine sulfoximine, was administered to mice, there was, however, a marked decrease in in vivo ammonia toxicity. The peak brain ammonia concentration following the injection of the LD 50 for untreated mice was actually significantly higher in the methionine sulfoximine-treated mice because of an increase in the base-line brain ammonia concentration, and yet there were no deaths in the treated group. Methionine sulfoximine had an effect on endogenous ammonia metabolism, as evidenced by a doubling of the brain ammonia concentrations 2 hours after its administration that lasted for at least 24 hours. This inhibitor of the glutamine synthetase reaction also interfered with the detoxication of an exogenous dose of ammonia and the formation of glutamine from this ammonia load. These studies indicate that ammonia intoxication does not depend upon the mere presence of high cerebral ammonia levels, but is related to the so-called mechanism of detoxication by which ammonia enters into the cerebral metabolic cycles." @default.
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- W2412347745 title "EFFECT OF AN INHIBITOR OF GLUTAMINE SYNTHESIS (METHIONINE SULFOXIMINE) ON AMMONIA TOXICITY AND METABOLISM." @default.
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