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- W2412393514 abstract "To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model.The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.Four compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated.Compounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity." @default.
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- W2412393514 date "2008-08-01" @default.
- W2412393514 modified "2023-09-23" @default.
- W2412393514 title "[Studies on bioactive constituents of whole herbs of Vernonia cinerea]." @default.
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