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• W2412593547 abstract "Introduction: Pain is the key symptom of patients suffering of osteochondral lesion (OCL) of the ankle. However, its tissue origin and the pain inducing and modulating mechanisms remain controversial. Cartilage is aneural and unlikely causing pain. Contrary soft and bone tissue show rich nociceptive innervations. Routine radiographic imaging of OCL fails to visualize the pain inducing structure. Recent studies demonstrated the capability of planar scintigraphy and SPECT for localizing painful joints in degenerative joints conditions. However, a limited spatial resolution of bone scans compromises an accurate anatomical localization of an uptake. Single photon emission computed tomography – computed tomography (SPECT-CT) is a new hybrid imaging technique allowing perfect overlay of functional and anatomical images. In OCL, SPECT-CT identifies the exact location of an OCL and determines the spatial extent of pathological bone remodeling. We conducted a study to evaluate the correlation between pathological uptake within an OCL and pain experienced by patients. Methods: 15 patients (7 female, 8 male; mean age 39, range 20–61 years) were assessed for unilateral OCL of the talus (13 joints) or distal tibia (2 joints). Radiological imaging of the foot and ankle consisted of plain radiographs, MRI and SPECT-CT. Clinical examination included range of motion (ROM), AOFAS Ankle-Hind-foot Scale, and pain status measured by the visual analogue scale (VAS). On completion of radiological and clinical assessment, patients were referred to the interventional radiology department for a diagnostic ankle injection. CTguided ankle joint injection with local anesthetics and iodine contrast medium was performed. Exact location of the deposit was documented. VAS score was assessed immediately post-infiltration and compared to the pre-interventional VAS score. Pain relief was defined as a reduction of VAS score of more than 50% of the pre-intervention score immediately after infiltration. The study was approved by the institutional review board and written informed patient consent was obtained. The study was carried out in accordance with the World Medical Association Declaration of Helsinki. Results: All infiltrations were technically successful. Pre-interventional VAS score was 5.3 (range 2 - 10; SD 2.33). Post-interventional VAS score was 1.1 (range 2 – 4; SD 1.45). This difference was statistically significant (p Discussion: The results of our study show a highly significant correlation between pain in OCL and pathological uptake seen on SPECT-CT, indicating bone as a major contributor to pain in this disease. Hybrid SPECT-CT technique is a new and powerful approach to diagnosis and staging of osteochondral lesions and provides important data for adequate treatment." @default.
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• W2412593547 date "2010-10-01" @default.
• W2412593547 modified "2023-10-14" @default.
• W2412593547 title "PAIN IN OSTEOCHONDRAL LESIONS OF THE ANKLE JOINT" @default.
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