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- W2412644599 abstract "Abstract The direct-assay of cobalt and sheep erythropoietin in the nephrectomized rat revealed that removal of the kidneys reduced the erythropoietic response to cobalt but did not modify significantly the response to sheep erythropoietin. Neither sham operation nor peritoneal dialysis was observed to exert a significant influence on radioactive iron incorporation in the starved rat. A moderate elevation in plasma BUN occurred in tile dialyzed nephrectomized rats but did not modify the capacity of the nephrectomized rat to respond to erythropoietin. No significant change occurred in plasma potassium in the lavaged-nephrectomized rats. Bilateral nephrectomy was found to result in a significant reduction in total circulating red cell and blood volume. Plasma iron was significantly reduced by both nephrectomy and cobalt administration, but was not significantly influenced by sheep erythropoietin. The findings reported in these studies, as well as those of other workers, leaves little doubt that the kidney plays an active role in erythropoiesis. The existence of a permissive renal erythropoietic factor does not seem likely." @default.
- W2412644599 created "2016-06-24" @default.
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- W2412644599 date "1963-06-01" @default.
- W2412644599 modified "2023-10-01" @default.
- W2412644599 title "The Influence of Cobalt and Sheep Erythropoietin on Radioactive Iron Incorporation in RBC of Starved Intact and Nephrectomized Rats" @default.
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- W2412644599 doi "https://doi.org/10.1182/blood.v21.6.729.729" @default.
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