FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412700417> ?p ?o ?g. }

• W2412700417 endingPage "813" @default.
• W2412700417 startingPage "799" @default.
• W2412700417 abstract "Oxygen-derived free radicals and intracellular calcium overload have been implicated as mediators of myocardial ischemia/reperfusion injury. We hypothesized that free radical scavengers or calcium channel blockers could enhance the protection afforded the isolated, working rat heart by crystalloid cardioplegia against this type of injury at 37 degrees C. Hearts from 42 male rats in seven groups (n = 6) were studied in an isolated, working heart preparation measuring aortic flow (ml/min/gm dry wt), peak systolic pressure (mm Hg), coronary artery flow (ml/min/gm dry wt), and calculated coronary vascular resistance (dyne.sec.cm-5/gm dry wt). Creatine kinase and lactate dehydrogenase release were measured before ischemia and at various times during the postischemic reperfusion period. Time-matched control hearts (group 1) were perfused for 2 hours. After finding that 30 minutes of ischemia and 10 minutes of reperfusion (group 2) produced significant (p less than 0.01) functional impairment that was completely protected (group 3) by a preischemic bolus of St. Thomas' Hospital cardioplegic solution, we again found significant (p less than 0.01) functional impairment after 40 minutes of ischemia and 10 minutes (group 4) or 20 minutes (group 5) of reperfusion despite a preischemic bolus of St. Thomas' Hospital cardioplegic solution. Diltiazem (10 mg/L) plus St. Thomas' Hospital cardioplegic solution (group 6) did not significantly (p less than 0.01) enhance functional recovery. Addition of superoxide dismutase plus catalase (200 microns/ml) (group 7) produced marked improvement in functional recovery that did not differ significantly (p less than 0.01) from control results (group 1). The creatine kinase and lactate dehydrogenase data strongly supported the preceding functional data. Coronary flow and vascular resistance were not significantly (p less than 0.01) changed from control values in any group. We conclude that the addition of superoxide dismutase and catalase but not diltiazem to St. Thomas' Hospital cardioplegic solution can significantly enhance myocardial protection against normothermic ischemia/reperfusion injury. This implicates oxygen-derived free radicals as mediators of this type of injury." @default.
• W2412700417 created "2016-06-24" @default.
• W2412700417 creator A5005716713 @default.
• W2412700417 creator A5010006760 @default.
• W2412700417 creator A5043083295 @default.
• W2412700417 date "1988-05-01" @default.
• W2412700417 modified "2023-09-30" @default.
• W2412700417 title "Enhancement of crystalloid cardioplegic protection against global normothermic ischemia by superoxide dismutase plus catalase but not diltiazem in the isolated, working rat heart" @default.
• W2412700417 cites W1924692271 @default.
• W2412700417 cites W1973408614 @default.
• W2412700417 cites W1984876837 @default.
• W2412700417 cites W1985006670 @default.
• W2412700417 cites W1992377852 @default.
• W2412700417 cites W1992885520 @default.
• W2412700417 cites W1994280520 @default.
• W2412700417 cites W2005248670 @default.
• W2412700417 cites W2024560631 @default.
• W2412700417 cites W2034683799 @default.
• W2412700417 cites W2036486612 @default.
• W2412700417 cites W2038537849 @default.
• W2412700417 cites W2041757099 @default.
• W2412700417 cites W2047861107 @default.
• W2412700417 cites W2054158826 @default.
• W2412700417 cites W2067377891 @default.
• W2412700417 cites W2076298828 @default.
• W2412700417 cites W2084578767 @default.
• W2412700417 cites W2087560860 @default.
• W2412700417 cites W2102896366 @default.
• W2412700417 cites W2103922226 @default.
• W2412700417 cites W2110213928 @default.
• W2412700417 cites W2140233303 @default.
• W2412700417 cites W2142020029 @default.
• W2412700417 cites W2148161400 @default.
• W2412700417 cites W2396070378 @default.
• W2412700417 cites W2399490696 @default.
• W2412700417 cites W2410892011 @default.
• W2412700417 cites W2416878118 @default.
• W2412700417 cites W2418599777 @default.
• W2412700417 cites W2432374989 @default.
• W2412700417 cites W2474617437 @default.
• W2412700417 cites W4294530094 @default.
• W2412700417 cites W4321508393 @default.
• W2412700417 doi "https://doi.org/10.1016/s0022-5223(19)35690-9" @default.
• W2412700417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3361928" @default.
• W2412700417 hasPublicationYear "1988" @default.
• W2412700417 type Work @default.
• W2412700417 sameAs 2412700417 @default.
• W2412700417 citedByCount "16" @default.
• W2412700417 countsByYear W24127004172016 @default.
• W2412700417 crossrefType "journal-article" @default.
• W2412700417 hasAuthorship W2412700417A5005716713 @default.
• W2412700417 hasAuthorship W2412700417A5010006760 @default.
• W2412700417 hasAuthorship W2412700417A5043083295 @default.
• W2412700417 hasBestOaLocation W24127004171 @default.
• W2412700417 hasConcept C126322002 @default.
• W2412700417 hasConcept C164705383 @default.
• W2412700417 hasConcept C2775838275 @default.
• W2412700417 hasConcept C2776151105 @default.
• W2412700417 hasConcept C2776741139 @default.
• W2412700417 hasConcept C2778979269 @default.
• W2412700417 hasConcept C2780114680 @default.
• W2412700417 hasConcept C36880943 @default.
• W2412700417 hasConcept C42219234 @default.
• W2412700417 hasConcept C43376680 @default.
• W2412700417 hasConcept C519063684 @default.
• W2412700417 hasConcept C541997718 @default.
• W2412700417 hasConcept C71924100 @default.
• W2412700417 hasConceptScore W2412700417C126322002 @default.
• W2412700417 hasConceptScore W2412700417C164705383 @default.
• W2412700417 hasConceptScore W2412700417C2775838275 @default.
• W2412700417 hasConceptScore W2412700417C2776151105 @default.
• W2412700417 hasConceptScore W2412700417C2776741139 @default.
• W2412700417 hasConceptScore W2412700417C2778979269 @default.
• W2412700417 hasConceptScore W2412700417C2780114680 @default.
• W2412700417 hasConceptScore W2412700417C36880943 @default.
• W2412700417 hasConceptScore W2412700417C42219234 @default.
• W2412700417 hasConceptScore W2412700417C43376680 @default.
• W2412700417 hasConceptScore W2412700417C519063684 @default.
• W2412700417 hasConceptScore W2412700417C541997718 @default.
• W2412700417 hasConceptScore W2412700417C71924100 @default.
• W2412700417 hasIssue "5" @default.
• W2412700417 hasLocation W24127004171 @default.
• W2412700417 hasLocation W24127004172 @default.
• W2412700417 hasOpenAccess W2412700417 @default.
• W2412700417 hasPrimaryLocation W24127004171 @default.
• W2412700417 hasRelatedWork W1540630045 @default.
• W2412700417 hasRelatedWork W1969729986 @default.
• W2412700417 hasRelatedWork W1980647914 @default.
• W2412700417 hasRelatedWork W2005476372 @default.
• W2412700417 hasRelatedWork W2064543462 @default.
• W2412700417 hasRelatedWork W2121338658 @default.
• W2412700417 hasRelatedWork W2395139768 @default.
• W2412700417 hasRelatedWork W4043397 @default.
• W2412700417 hasRelatedWork W4246370998 @default.
• W2412700417 hasRelatedWork W88386246 @default.
• W2412700417 hasVolume "95" @default.
• W2412700417 isParatext "false" @default.
• W2412700417 isRetracted "false" @default.

• next