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- W2412776669 abstract "Regulators of G protein signaling (RGS) proteins of the B/R4 family are widely expressed in the cardiovascular system where their role in fine-tuning G protein signaling is critical to maintaining homeostasis. Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through Gq/11 and Gi/o classes of heterotrimeric G proteins. This chapter reviews accumulating evidence supporting a key role for RGS2 in vascular function and the implication of changes in RGS2 function and/or expression in the pathogenesis of blood pressure disorders, particularly hypertension. With such understanding, RGS2 and the signaling pathways it controls may emerge as novel targets for developing next-generation antihypertensive drugs/agents." @default.
- W2412776669 created "2016-06-24" @default.
- W2412776669 creator A5031831888 @default.
- W2412776669 creator A5057152088 @default.
- W2412776669 date "2015-01-01" @default.
- W2412776669 modified "2023-10-05" @default.
- W2412776669 title "Regulator of G Protein Signaling 2" @default.
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- W2412776669 doi "https://doi.org/10.1016/bs.pmbts.2015.02.001" @default.
- W2412776669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4955401" @default.
- W2412776669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26123303" @default.
- W2412776669 hasPublicationYear "2015" @default.
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