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• W2412806083 abstract "To investigate the relationship between cognitive impairment and global DNA methylation in aluminum (Al) potroom workers.A total of 366 Al-exposed workers were investigated, and their cognitive functions were assessed with the Mini-Mental State Examination (MMSE). Aluminum in serum was quantified using graphite furnace atomic absorption spectrometry. Global DNA methylation was analyzed in whole blood using an enzyme-linked immunosorbent assay-like reaction.Mini-Mental State Examination scores and global DNA methylation decreased with the increase of serum Al concentration. Forty-three mild cognitive impairment (MCI) people were diagnosed. Global DNA methylation of the MCI was lower than the non-MCI. Multiple logistic analysis showed that the Al-exposed workers had lower global DNA methylation and higher serum Al concentration and were at the higher risk of MCI.Long-term exposure to Al may cause MCI. Mild cognitive impairment was significantly associated with global DNA methylation in blood." @default.
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• W2412806083 date "2015-07-01" @default.
• W2412806083 modified "2023-10-15" @default.
• W2412806083 title "The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers" @default.
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• W2412806083 doi "https://doi.org/10.1097/jom.0000000000000474" @default.
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