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- W2412855433 abstract "Many studies show that flavonoids have a numerous biological properties, antimicrobial effects included. It is also known that rutin is able to increase the antibacterial activity of other compounds.Starting from these facts, we synthesised some water soluble rutin derivatives treating rutin with 1, 3-dichloro-2-propanol, 1-bromo-3-chloro-propane, 2-dibromethane, and dibrommethane, and than with 7-amino-cephalosporanic acid. The antimicrobial activity of the new compounds was determined by disc diffusion method.Molecular formula, weight, yield, melting points and solubility of the new derivatives have been determined. Elemental analysis and spectral analysis (UV and IR) confirmed the structure of new compounds. CONCLUSIONS. These derivatives are water-soluble and have a good antimicrobial activity, both on Gram-positive and Gram-negative bacteria, comparable with that of tetracycline." @default.
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- W2412855433 date "2012-01-27" @default.
- W2412855433 modified "2023-10-17" @default.
- W2412855433 title "[Synthesis and characterization of some new rutin and 7-aminocephalosporanic acid derivatives]." @default.
- W2412855433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22276483" @default.
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