Matches in SemOpenAlex for { <https://semopenalex.org/work/W2412864259> ?p ?o ?g. }
- W2412864259 endingPage "1310" @default.
- W2412864259 startingPage "1299" @default.
- W2412864259 abstract "Although accumulating evidence has suggested that microRNAs (miRNAs) have a serious impact on cognitive function and are associated with the etiology of several neuropsychiatric disorders, their expression in sevoflurane-induced neurotoxicity in the developing brain has not been characterized. In the present study, the miRNAs expression pattern in neonatal hippocampus samples (24 h after sevoflurane exposure) was investigated and 9 miRNAs were selected, which were associated with brain development and cognition in order to perform a bioinformatic analysis. Previous microfluidic chip assay had detected 29 upregulated and 24 downregulated miRNAs in the neonatal rat hippocampus, of which 7 selected deregulated miRNAs were identified by the quantitative polymerase chain reaction. A total of 85 targets of selected deregulated miRNAs were analyzed using bioinformatics and the main enriched metabolic pathways, mitogen-activated protein kinase and Wnt pathways may have been involved in molecular mechanisms with regard to neuronal cell body, dendrite and synapse. The observations of the present study provided a novel understanding regarding the regulatory mechanism of miRNAs underlying sevoflurane-induced neurotoxicity, therefore benefitting the improvement of the prevention and treatment strategies of volatile anesthetics related neurotoxicity." @default.
- W2412864259 created "2016-06-24" @default.
- W2412864259 creator A5021075276 @default.
- W2412864259 creator A5022473761 @default.
- W2412864259 creator A5023245885 @default.
- W2412864259 creator A5028438475 @default.
- W2412864259 creator A5067005516 @default.
- W2412864259 creator A5078652384 @default.
- W2412864259 creator A5082226210 @default.
- W2412864259 date "2016-06-13" @default.
- W2412864259 modified "2023-10-18" @default.
- W2412864259 title "Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis" @default.
- W2412864259 cites W144423133 @default.
- W2412864259 cites W1983535614 @default.
- W2412864259 cites W1990487655 @default.
- W2412864259 cites W1996257212 @default.
- W2412864259 cites W1996311925 @default.
- W2412864259 cites W2000502968 @default.
- W2412864259 cites W2000686822 @default.
- W2412864259 cites W2004593687 @default.
- W2412864259 cites W2013021876 @default.
- W2412864259 cites W2014448450 @default.
- W2412864259 cites W2015242325 @default.
- W2412864259 cites W2016185676 @default.
- W2412864259 cites W2022567291 @default.
- W2412864259 cites W2024591810 @default.
- W2412864259 cites W2025842601 @default.
- W2412864259 cites W2026141871 @default.
- W2412864259 cites W2030937749 @default.
- W2412864259 cites W2031530650 @default.
- W2412864259 cites W2033910468 @default.
- W2412864259 cites W2034775638 @default.
- W2412864259 cites W2036450246 @default.
- W2412864259 cites W2037778691 @default.
- W2412864259 cites W2039047987 @default.
- W2412864259 cites W2040655387 @default.
- W2412864259 cites W2042735193 @default.
- W2412864259 cites W2045406219 @default.
- W2412864259 cites W2052898737 @default.
- W2412864259 cites W2057405638 @default.
- W2412864259 cites W2058847274 @default.
- W2412864259 cites W2058904604 @default.
- W2412864259 cites W2059988722 @default.
- W2412864259 cites W2072498594 @default.
- W2412864259 cites W2074175204 @default.
- W2412864259 cites W2075273939 @default.
- W2412864259 cites W2077115769 @default.
- W2412864259 cites W2082686201 @default.
- W2412864259 cites W2091512692 @default.
- W2412864259 cites W2092023996 @default.
- W2412864259 cites W2092963962 @default.
- W2412864259 cites W2093765498 @default.
- W2412864259 cites W2100569554 @default.
- W2412864259 cites W2103972201 @default.
- W2412864259 cites W2106123906 @default.
- W2412864259 cites W2107277218 @default.
- W2412864259 cites W2111031043 @default.
- W2412864259 cites W2111585311 @default.
- W2412864259 cites W2112761850 @default.
- W2412864259 cites W2117391623 @default.
- W2412864259 cites W2118182274 @default.
- W2412864259 cites W2120821369 @default.
- W2412864259 cites W2121956895 @default.
- W2412864259 cites W2122818487 @default.
- W2412864259 cites W2123159256 @default.
- W2412864259 cites W2125860097 @default.
- W2412864259 cites W2133150393 @default.
- W2412864259 cites W2139008185 @default.
- W2412864259 cites W2140383855 @default.
- W2412864259 cites W2140594985 @default.
- W2412864259 cites W2142005071 @default.
- W2412864259 cites W2152957747 @default.
- W2412864259 cites W2159558399 @default.
- W2412864259 cites W2160834543 @default.
- W2412864259 cites W2171288744 @default.
- W2412864259 cites W2192080449 @default.
- W2412864259 cites W2324564160 @default.
- W2412864259 cites W4365997082 @default.
- W2412864259 cites W3140345342 @default.
- W2412864259 doi "https://doi.org/10.3892/etm.2016.3452" @default.
- W2412864259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4998092" @default.
- W2412864259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27588052" @default.
- W2412864259 hasPublicationYear "2016" @default.
- W2412864259 type Work @default.
- W2412864259 sameAs 2412864259 @default.
- W2412864259 citedByCount "20" @default.
- W2412864259 countsByYear W24128642592017 @default.
- W2412864259 countsByYear W24128642592018 @default.
- W2412864259 countsByYear W24128642592019 @default.
- W2412864259 countsByYear W24128642592020 @default.
- W2412864259 countsByYear W24128642592021 @default.
- W2412864259 countsByYear W24128642592022 @default.
- W2412864259 crossrefType "journal-article" @default.
- W2412864259 hasAuthorship W2412864259A5021075276 @default.
- W2412864259 hasAuthorship W2412864259A5022473761 @default.
- W2412864259 hasAuthorship W2412864259A5023245885 @default.
- W2412864259 hasAuthorship W2412864259A5028438475 @default.
- W2412864259 hasAuthorship W2412864259A5067005516 @default.