Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413100740> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2413100740 endingPage "66" @default.
- W2413100740 startingPage "1959" @default.
- W2413100740 abstract "A soft agar colony formation assay, so called human tumor clonogenic assay (HTC assay) similar to that originally described by Salmon and colleagues, was utilized to measure the sensitivity of a total of 85 urologic malignancies including 36 urothelial cell carcinomas, 41 renal cell carcinomas, 5 testicular tumors, and 3 Wilms' tumors to anticancer drugs. In addition, the results obtained were compared with those of a novel dye exclusion method (NDE assay) described by Weisenthal and colleagues. The NDE assay was utilized to measure the sensitivity of a total of 63 urologic malignancies including 28 urothelial cell carcinomas, 25 renal cell carcinomas, 6 testicular tumors, and 4 Wilms' tumors to anticancer agents. In both assay series, the concentration of anticancer drugs tested was approximately one tenth of the maximum serum level achievable after single bolus injection. The colony forming rate inhibition of 70% or more in the HTC assay and the cell survival rate of 30% or less in the NDE assay were defined as sensitive. Sixteen of the 36 urothelial cell carcinomas, 11 of the 41 renal cell carcinomas, and 1 of the 5 testicular tumors had both more than 30 colonies grown in control plates and enough cells in the specimens to provide at least one drug sensitivity testing. In urothelial cell carcinomas, 3 out of 13 tumors were sensitive to adriamycin, 3 out of 16 to cis-platinum, and 4 out of 15 to carboquone. In renal cell carcinomas, 2 out of 9 tumors were sensitive to adriamycin, 4 out of 11 to vinblastine, and none of 4 to Interferon alpha.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2413100740 created "2016-06-24" @default.
- W2413100740 creator A5002282991 @default.
- W2413100740 creator A5004301901 @default.
- W2413100740 creator A5014155722 @default.
- W2413100740 creator A5063237684 @default.
- W2413100740 creator A5076345526 @default.
- W2413100740 creator A5077406542 @default.
- W2413100740 date "1986-12-01" @default.
- W2413100740 modified "2023-09-26" @default.
- W2413100740 title "[An in vitro chemosensitivity study using human tumor clonogenic assay in urologic malignancies]." @default.
- W2413100740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3825833" @default.
- W2413100740 hasPublicationYear "1986" @default.
- W2413100740 type Work @default.
- W2413100740 sameAs 2413100740 @default.
- W2413100740 citedByCount "0" @default.
- W2413100740 crossrefType "journal-article" @default.
- W2413100740 hasAuthorship W2413100740A5002282991 @default.
- W2413100740 hasAuthorship W2413100740A5004301901 @default.
- W2413100740 hasAuthorship W2413100740A5014155722 @default.
- W2413100740 hasAuthorship W2413100740A5063237684 @default.
- W2413100740 hasAuthorship W2413100740A5076345526 @default.
- W2413100740 hasAuthorship W2413100740A5077406542 @default.
- W2413100740 hasConcept C117262875 @default.
- W2413100740 hasConcept C126894567 @default.
- W2413100740 hasConcept C142724271 @default.
- W2413100740 hasConcept C1491633281 @default.
- W2413100740 hasConcept C2777472916 @default.
- W2413100740 hasConcept C2777540882 @default.
- W2413100740 hasConcept C2778076430 @default.
- W2413100740 hasConcept C2779762690 @default.
- W2413100740 hasConcept C2910041100 @default.
- W2413100740 hasConcept C3020616263 @default.
- W2413100740 hasConcept C502942594 @default.
- W2413100740 hasConcept C54355233 @default.
- W2413100740 hasConcept C71924100 @default.
- W2413100740 hasConcept C86803240 @default.
- W2413100740 hasConceptScore W2413100740C117262875 @default.
- W2413100740 hasConceptScore W2413100740C126894567 @default.
- W2413100740 hasConceptScore W2413100740C142724271 @default.
- W2413100740 hasConceptScore W2413100740C1491633281 @default.
- W2413100740 hasConceptScore W2413100740C2777472916 @default.
- W2413100740 hasConceptScore W2413100740C2777540882 @default.
- W2413100740 hasConceptScore W2413100740C2778076430 @default.
- W2413100740 hasConceptScore W2413100740C2779762690 @default.
- W2413100740 hasConceptScore W2413100740C2910041100 @default.
- W2413100740 hasConceptScore W2413100740C3020616263 @default.
- W2413100740 hasConceptScore W2413100740C502942594 @default.
- W2413100740 hasConceptScore W2413100740C54355233 @default.
- W2413100740 hasConceptScore W2413100740C71924100 @default.
- W2413100740 hasConceptScore W2413100740C86803240 @default.
- W2413100740 hasIssue "12" @default.
- W2413100740 hasLocation W24131007401 @default.
- W2413100740 hasOpenAccess W2413100740 @default.
- W2413100740 hasPrimaryLocation W24131007401 @default.
- W2413100740 hasRelatedWork W1988045190 @default.
- W2413100740 hasRelatedWork W2005149537 @default.
- W2413100740 hasRelatedWork W2035352153 @default.
- W2413100740 hasRelatedWork W2075312477 @default.
- W2413100740 hasRelatedWork W2089854972 @default.
- W2413100740 hasRelatedWork W2100893712 @default.
- W2413100740 hasRelatedWork W2253694187 @default.
- W2413100740 hasRelatedWork W2413100740 @default.
- W2413100740 hasRelatedWork W4226465212 @default.
- W2413100740 hasRelatedWork W1970801557 @default.
- W2413100740 hasVolume "32" @default.
- W2413100740 isParatext "false" @default.
- W2413100740 isRetracted "false" @default.
- W2413100740 magId "2413100740" @default.
- W2413100740 workType "article" @default.