Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413102516> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2413102516 endingPage "A587" @default.
- W2413102516 startingPage "A587" @default.
- W2413102516 abstract "To evaluate the cost-effectiveness of an integrase inhibitor (INI), dolutegravir (DTG), in combination with abacavir(ABC)/lamivudine(3TC) in France, in treatment-naïve (TN) HIV adult patients. The ARAMIS microsimulation Markov model, including HIV health states with and without opportunistic infection, evaluates costs and effects of first line options including INIs (raltegravir [RAL], elvitegravir/c), protease inhibitors (PI) (darunavir [DRV/r], atazanavir/r, lopinavir [LPV/r]), efavirenz (EFV) and rilpivirine at a life time horizon with a monthly cycle length. Efficacy and safety data were derived from phase III studies (SPRING 2, FLAMINGO and SINGLE including comparators RAL, DRV/r and EFV respectively) and network meta-analyses for other comparators. Treatment algorithms were based on French guidelines and experts opinion accounting for patient’s treatment history, including INI resistance status. Costs, from a collective perspective included routine HIV and opportunistic infection care, and death. The model showed DTG/ABC/3TC was more effective than all other recommended regimens: patients stayed longer on first line, and lived longer and healthier (incremental life years ranged from 0.305 to 0.71 and QALYs from 0.085 to 0.28 versus RAL and LPV/r). With the exception of EFV, DTG was dominant compared to all strategies, with the largest cost savings for INIs (incremental costs of -€21,556 for RAL). The cost per QALY gained (ICER) for DTG compared to EFV was €6,939 (incremental QALYs and costs of 0.10 and +€692, respectively). Deterministic sensitivity analyses (DSA) showed that DTG was dominant compared to INIs and PIs in all DSA. Compared to EFV, the ICER was most sensitive to time horizon, resistance parameters, and late failure probability. DTG/ABC/3TC is cost-effective in the management of HIV TN patients in France. These results are mainly explained by the lower price of DTG/3TC/ABC compared to INIs and PIs, DTG’s superior efficacy and high barrier to resistance." @default.
- W2413102516 created "2016-06-24" @default.
- W2413102516 creator A5000727127 @default.
- W2413102516 creator A5028675175 @default.
- W2413102516 creator A5043721868 @default.
- W2413102516 creator A5075934263 @default.
- W2413102516 creator A5083251507 @default.
- W2413102516 creator A5083391070 @default.
- W2413102516 creator A5085697637 @default.
- W2413102516 date "2015-11-01" @default.
- W2413102516 modified "2023-10-18" @default.
- W2413102516 title "Cost-Effectiveness of Dolutegravir/Abacavir/Lamivudine in Hiv-1 Treatment Naive Patients in France" @default.
- W2413102516 doi "https://doi.org/10.1016/j.jval.2015.09.1497" @default.
- W2413102516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26533296" @default.
- W2413102516 hasPublicationYear "2015" @default.
- W2413102516 type Work @default.
- W2413102516 sameAs 2413102516 @default.
- W2413102516 citedByCount "2" @default.
- W2413102516 countsByYear W24131025162016 @default.
- W2413102516 countsByYear W24131025162018 @default.
- W2413102516 crossrefType "journal-article" @default.
- W2413102516 hasAuthorship W2413102516A5000727127 @default.
- W2413102516 hasAuthorship W2413102516A5028675175 @default.
- W2413102516 hasAuthorship W2413102516A5043721868 @default.
- W2413102516 hasAuthorship W2413102516A5075934263 @default.
- W2413102516 hasAuthorship W2413102516A5083251507 @default.
- W2413102516 hasAuthorship W2413102516A5083391070 @default.
- W2413102516 hasAuthorship W2413102516A5085697637 @default.
- W2413102516 hasBestOaLocation W24131025161 @default.
- W2413102516 hasConcept C142462285 @default.
- W2413102516 hasConcept C159047783 @default.
- W2413102516 hasConcept C177713679 @default.
- W2413102516 hasConcept C2522874641 @default.
- W2413102516 hasConcept C2776738588 @default.
- W2413102516 hasConcept C2777302000 @default.
- W2413102516 hasConcept C2777869810 @default.
- W2413102516 hasConcept C2778414717 @default.
- W2413102516 hasConcept C2778723075 @default.
- W2413102516 hasConcept C2779182219 @default.
- W2413102516 hasConcept C2779465607 @default.
- W2413102516 hasConcept C2779502633 @default.
- W2413102516 hasConcept C2780404665 @default.
- W2413102516 hasConcept C2780593183 @default.
- W2413102516 hasConcept C2781432083 @default.
- W2413102516 hasConcept C2993143319 @default.
- W2413102516 hasConcept C3013748606 @default.
- W2413102516 hasConcept C71924100 @default.
- W2413102516 hasConceptScore W2413102516C142462285 @default.
- W2413102516 hasConceptScore W2413102516C159047783 @default.
- W2413102516 hasConceptScore W2413102516C177713679 @default.
- W2413102516 hasConceptScore W2413102516C2522874641 @default.
- W2413102516 hasConceptScore W2413102516C2776738588 @default.
- W2413102516 hasConceptScore W2413102516C2777302000 @default.
- W2413102516 hasConceptScore W2413102516C2777869810 @default.
- W2413102516 hasConceptScore W2413102516C2778414717 @default.
- W2413102516 hasConceptScore W2413102516C2778723075 @default.
- W2413102516 hasConceptScore W2413102516C2779182219 @default.
- W2413102516 hasConceptScore W2413102516C2779465607 @default.
- W2413102516 hasConceptScore W2413102516C2779502633 @default.
- W2413102516 hasConceptScore W2413102516C2780404665 @default.
- W2413102516 hasConceptScore W2413102516C2780593183 @default.
- W2413102516 hasConceptScore W2413102516C2781432083 @default.
- W2413102516 hasConceptScore W2413102516C2993143319 @default.
- W2413102516 hasConceptScore W2413102516C3013748606 @default.
- W2413102516 hasConceptScore W2413102516C71924100 @default.
- W2413102516 hasIssue "7" @default.
- W2413102516 hasLocation W24131025161 @default.
- W2413102516 hasOpenAccess W2413102516 @default.
- W2413102516 hasPrimaryLocation W24131025161 @default.
- W2413102516 hasRelatedWork W1990854011 @default.
- W2413102516 hasRelatedWork W2214278004 @default.
- W2413102516 hasRelatedWork W2392737066 @default.
- W2413102516 hasRelatedWork W2411561522 @default.
- W2413102516 hasRelatedWork W2561114165 @default.
- W2413102516 hasRelatedWork W2565202933 @default.
- W2413102516 hasRelatedWork W2566908671 @default.
- W2413102516 hasRelatedWork W3016565612 @default.
- W2413102516 hasRelatedWork W3048312779 @default.
- W2413102516 hasRelatedWork W4240243247 @default.
- W2413102516 hasVolume "18" @default.
- W2413102516 isParatext "false" @default.
- W2413102516 isRetracted "false" @default.
- W2413102516 magId "2413102516" @default.
- W2413102516 workType "article" @default.