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- W2413141025 abstract "With the advent of improved vectors for DNA delivery, somatic gene therapeutic approaches have expanded rapidly in the last few years. The vast majority of applications include ex vivo and in vivo protocols in patients postnatally. Nonetheless there is increasing interest and compelling reasons to consider prenatal application of somatic gene therapy (1,2. In the current chapter, we will review theoretical, ethical, and experimental support for in utero gene therapy and then outline the methodology and large animal model we are currently using to consider retrovirus-mediated gene transfer to fetal lung. In this latter regard, the candidate inherited disorder is cystic fibrosis and the reader is referred to Chapters 1 and 12 in this volume." @default.
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- W2413141025 date "2003-11-14" @default.
- W2413141025 modified "2023-09-27" @default.
- W2413141025 title "Methods for Retrovirus-Mediated Gene Transfer to Fetal Lung" @default.
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- W2413141025 doi "https://doi.org/10.1385/0-89603-484-4:185" @default.
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