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- W2413146532 abstract "Objective To investigate the effects of alendronate(Alen)on the prevention of systemic glueocortieoid-induced osteopomsis in patients with rheumatic diseases.Methods 140 patients suffering from rheumatic diseases,including systemic lupus erythematosus,polymyositis,dermatomyositis,and Sj(o)gren's syndrome,with normal boRe mineral density(BMD)and treated with oral glucocorticoids Were randomly divided into 2 groups:Alen+calcium group(n=74)receiving Aten 10 mg once a day and caltrate D 600 0.6 g once a day for 24 weeks and control group(n=66)receiving eahrate D 600 0.6 g once a day for 24 weeks.The BMD and biomarkers of bone turnover were measured at baseline and 24 weeks afterinitiating glucocorticoid therapy.Results After 24 weeks.the BMD Values at lumbar spine,femoral neck,major troehanter,and Ward's triangle increased by 6.1%,6.3%,3.3%,and 2.2% respectively compared with those at baseline(all P＜0.05),however,those of the control group decreased by 8.7%,9.1%,7.7%,and 6.4%respectively(P＜0.01,P＜0.05),and the BMD levels at lumbar spine and femoral neck 24 weeks Iater of the Alen+calcium group were both higher than those of the control group (P＜0.01,P＜0.05).24 weeks later the level of urine cross linked N-telopeptides of type Ⅰ collagen (NTX)of the Alert+calcium group decreased(P＜0.05),and the blood osteocalcin(BGP)of the Alen+calcium group increased,however,not significantly(P＞0.05).There were no significant differences in scram AKP and BGP and urine NTX 24 weeks later between these 2 groups.Conclusion Improving BMD,alendronate plays an important role in the prevention of glueocorticoid-induced osteoporosis.However,calcium treatment alone fails to prevent the loss of bone.Key words: Alendronate; Bone mineral density; Glueocorticoid; Osteoporosis" @default.
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- W2413146532 date "2008-07-15" @default.
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- W2413146532 title "[Alendronate prevents steroid-induced osteoporosis in patients with rheumatic diseases]." @default.
- W2413146532 doi "https://doi.org/10.3321/j.issn:0376-2491.2008.27.006" @default.
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