Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413200711> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2413200711 endingPage "5" @default.
- W2413200711 startingPage "561" @default.
- W2413200711 abstract "Non-steroidal anti-inflammatory drugs(NSAIDs) have a potential to cause mucosal injury in the gastrointestinal tract. Inhibitions of cyclooxygenase, one of the targets of NSAIDs and direct cytotoxic effects of NSAIDs, are reported to be involved in NSAIDs-related mucosal damage. It is estimated that 15-30% of patients taking NSAIDs develop gastroduodenal ulcers, 2% of patients have life-threatening complications. Normal gastroduodenal mucosa expresses only COX-1, and it is reported that NSAIDs are more strongly inhibiting COX-1 are more harmful to gastroduodenal mucosa. Therefore, selective COX-2 inhibitors have been developed as safer NSAIDs than non-selective NSAIDs. Recent reports have, however, shown that COX-2 is expressing in gastroduodenal ulcers and H. pylori infection, suggesting that COX-2 plays an important role in mucosal healing. In this article, we discuss whether COX-2 selective inhibitors are able to prevent NSAIDs-associated ulceration." @default.
- W2413200711 created "2016-06-24" @default.
- W2413200711 creator A5029028447 @default.
- W2413200711 creator A5051625411 @default.
- W2413200711 creator A5060389174 @default.
- W2413200711 date "2004-03-01" @default.
- W2413200711 modified "2023-09-23" @default.
- W2413200711 title "[Are COX-2 inhibitors truly able to prevent NSAIDs-associated ulcer?]." @default.
- W2413200711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15038104" @default.
- W2413200711 hasPublicationYear "2004" @default.
- W2413200711 type Work @default.
- W2413200711 sameAs 2413200711 @default.
- W2413200711 citedByCount "1" @default.
- W2413200711 crossrefType "journal-article" @default.
- W2413200711 hasAuthorship W2413200711A5029028447 @default.
- W2413200711 hasAuthorship W2413200711A5051625411 @default.
- W2413200711 hasAuthorship W2413200711A5060389174 @default.
- W2413200711 hasConcept C126322002 @default.
- W2413200711 hasConcept C181199279 @default.
- W2413200711 hasConcept C185592680 @default.
- W2413200711 hasConcept C2777031258 @default.
- W2413200711 hasConcept C2779689624 @default.
- W2413200711 hasConcept C2780512811 @default.
- W2413200711 hasConcept C2780656511 @default.
- W2413200711 hasConcept C3018964098 @default.
- W2413200711 hasConcept C55493867 @default.
- W2413200711 hasConcept C71924100 @default.
- W2413200711 hasConcept C90924648 @default.
- W2413200711 hasConcept C98274493 @default.
- W2413200711 hasConceptScore W2413200711C126322002 @default.
- W2413200711 hasConceptScore W2413200711C181199279 @default.
- W2413200711 hasConceptScore W2413200711C185592680 @default.
- W2413200711 hasConceptScore W2413200711C2777031258 @default.
- W2413200711 hasConceptScore W2413200711C2779689624 @default.
- W2413200711 hasConceptScore W2413200711C2780512811 @default.
- W2413200711 hasConceptScore W2413200711C2780656511 @default.
- W2413200711 hasConceptScore W2413200711C3018964098 @default.
- W2413200711 hasConceptScore W2413200711C55493867 @default.
- W2413200711 hasConceptScore W2413200711C71924100 @default.
- W2413200711 hasConceptScore W2413200711C90924648 @default.
- W2413200711 hasConceptScore W2413200711C98274493 @default.
- W2413200711 hasIssue "3" @default.
- W2413200711 hasLocation W24132007111 @default.
- W2413200711 hasOpenAccess W2413200711 @default.
- W2413200711 hasPrimaryLocation W24132007111 @default.
- W2413200711 hasRelatedWork W1976460300 @default.
- W2413200711 hasRelatedWork W1992780682 @default.
- W2413200711 hasRelatedWork W2013249439 @default.
- W2413200711 hasRelatedWork W2020500084 @default.
- W2413200711 hasRelatedWork W2023574732 @default.
- W2413200711 hasRelatedWork W2089056350 @default.
- W2413200711 hasRelatedWork W2144606035 @default.
- W2413200711 hasRelatedWork W2158251394 @default.
- W2413200711 hasRelatedWork W2162216950 @default.
- W2413200711 hasRelatedWork W2090098738 @default.
- W2413200711 hasVolume "62" @default.
- W2413200711 isParatext "false" @default.
- W2413200711 isRetracted "false" @default.
- W2413200711 magId "2413200711" @default.
- W2413200711 workType "article" @default.