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- W2413215798 abstract "Objective To explore the association between the common variations of 2q31.1 (rs12621278,G),3q21.3 (rs10934853,C),4q2 (rs17021918,T),4q2 (rs7679673,C),6q25.3 (rs9364554,T) and prostate cancer (PCa) in Beijing urban crowd,and to understand the relationship in PCa patients in the genes type and clinical,genetic,dietary habits,hobbies,age and so on.Methods A case-control method was performed,consisting of 124 patients with prostate cancer and 138 PCa-free healthy controls with age and gender matched.Information with PCa patient clinical,genetic,dietary habits,hobbies,age and so on were collected.PCR-HRM was used to determine the distribution of allele and genotype frequency of 2q31.1 (rs12621278,G),3q21.3 (rs10934853,C),4q2 (rs17021918,T),4q2 (rs7679673,C),6q25.3 (rs9364554,T).Results There was no obverse distribution of difference in those five SNPs' allele or genotype frequency (P ＞ 0.05).A CC haplotype which composed of 4q2(rs17021918,T) and 4q2 (rs7679673,C) was obverse distributed between two groups (P =0.04,OR =1.68,95％ CI =1.03-2.76).Analysis showed that 3q21.3 (rs10934853,C) genotype frequency in the distribution of Gleason scores ≥7,4q2 (rs17021918,T) genotype frequency in the distribution of BMI ＜ 25and middle or low risk level,and 6q25.3 (rs9364554,T) genotype frequency in the distribution of Staging ＜ T2 had significant difference (P =0.04,P =0.04,P =0.03,P =0.05).Conclusions There was no significant association between 2q31.1 (rs12621278,G),3q21.3 (rs10934853,C),4q2 (rs17021918,T),4q2 (rs7679673,C),6q25.3 (rs9364554,T) and PCa in our samples.They may not be genetic risk factors of PCa in Chinese population.The CC haplotype composed of 4q2 (rs17021918,T) and 4q2 (rs7679673,C) may be risk assessment as a reference.Key words: Prostate cancer; Common variation; Association" @default.
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- W2413215798 date "2013-01-15" @default.
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- W2413215798 title "Related study of common variations in 2q31.1, 3q21.3, 4q2 and 6q25.3 and prostate cancer in chinese population" @default.
- W2413215798 doi "https://doi.org/10.3760/cma.j.issn.1000-6702.2013.01.018" @default.
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