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• W2413223232 startingPage "757" @default.
• W2413223232 abstract "Single rat hepatocytes microinjected with aequorin generate oscillations in cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated with agonists acting through the phosphoinositide signalling pathway. The duration of these transients has been shown to be characteristic of the stimulating agonist, so that transients of very different duration can be induced in the same individual hepatocyte by different agonists. In a previous study we have shown that ADP and ATP, which are believed to act through a single P2y-purinoceptor species, elicit very different [Ca2+]i responses in most of the hepatocytes. We have interpreted this as evidence for two Ca(2+)-mobilizing purinoceptors. The methylated derivative of ATP, adenosine 5'-[alpha beta-methylene]-triphosphate (pp[CH2]pA), is only a weak P2y-purinoceptor agonist. When 100 microM pp[CH2]pA was supplied to aequorin-injected hepatocytes, there was no effect on [Ca2+]i. However, 25 microM pp[CH2]pA co-supplied with ATP causes a potentiation of the [Ca2+]i response in most of the hepatocytes. The effect was specific for ATP-induced transients; [Ca2+]i transients induced by other agonists, and importantly by ADP, were not affected by addition of pp[CH2]pA. This further illustrates differences in the actions of ADP and ATP, strengthening the argument for separate receptors for these nucleotides." @default.
• W2413223232 created "2016-06-24" @default.
• W2413223232 creator A5021381146 @default.
• W2413223232 creator A5025181117 @default.
• W2413223232 creator A5068432827 @default.
• W2413223232 date "1993-08-01" @default.
• W2413223232 modified "2023-10-16" @default.
• W2413223232 title "Adenosine 5′-[α β-methylene]triphosphate potentiates the oscillatory cytosolic Ca2+ responses of hepatocytes to ATP, but not to ADP" @default.
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• W2413223232 doi "https://doi.org/10.1042/bj2930757" @default.
• W2413223232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134431" @default.
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• W2413223232 hasPublicationYear "1993" @default.
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