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- W2413236431 abstract "Introduction: The purpose of the study was to evaluate salivary gland dysfunction after a high-dose radioiodine therapy administered topatients with differentiated thyroid carcinoma. Material and methods: The study group consisted of 60 patients (age range 20-78 years). Detailed history about complaints from the oralcavity were taken, followed by the ultrasonography and dynamic scintigraphy. The procedure was performed on 40 patients before andone year after radioiodine administration, and a single-time on 20 patients treated with multiple doses in the past. Results: Data analysis shows no statistically significant increase of subjective sufferings after first radioiodine dose (60-150 mCi), smalldecrease of uptake ratio UR ( i.e. average dose of 250 mCi) informed more often about problems connected with decreased salivation (~ 20% patients), in scintigraphythere was a reduction of parotid UR 21-23% and parotid maximal secretion MS 7-13%. Ultrasonography did not show changes in salivaryglands echogenicity after 12 months from the first dose of 131 I. There was no close relationship between scintigraphically revealed dysfunctionsand the occurrence of complaints; no correlation between appearance of acute sialadenitis symptoms after radioiodine therapy andsubsequent dysfunctions. Conclusions: The main conclusion is that a single dose of 131 I has no significant influence on salivary gland function; a repeated high-dosestherapy is connected with an essential risk of side-effect occurrence. Scintigraphy can evaluate salivary gland function with high sensitivity.Parotid glands are more radiosensitive than submandibular. (Pol J Endocrinol 2008; 59 (5): 403-410)" @default.
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- W2413236431 date "2008-09-01" @default.
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- W2413236431 title "Salivary gland damage after 131I therapy in patients with differentiated thyroid cancer. Preliminary report" @default.
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