FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2413257246> ?p ?o ?g. }

• W2413257246 abstract "Characterizing factors that contribute to transcript variability is necessary before molecular endpoints are widely adopted as biomarkers for environmental monitoring programs and risk assessment. Here, we employed a meta-analysis approach to understand how reproductive stage, breeding strategy, and tissue type influence transcript variability in multiple fish species. Transcript abundance from the scientific literature was examined by method of quantification (qPCR or microarray), and the extracted data were used to calculate the coefficient of variation (CoV) for each transcript. Based on qPCR data, variability in the abundance of estrogen receptor 1 and hydroxysteroid dehydrogenase 3b was dependent upon reproductive stage and/or breeding strategy in the female ovaries. The variability of other transcripts in the steroid biosynthesis pathway as well as other steroid receptors did not depend upon sex, breeding strategy, or reproductive stage. Variability estimates were used to determine sample size requirements for detecting specific critical effects in molecular endpoints. It was estimated that only 37.8% of published studies used in the qPCR meta-analysis had sufficient experimental power (0.8) to detect a 2-fold expression difference in a transcript. To build upon these analyses, microarray data were used to measure overall variability of the transcriptome, and it was determined that the vitellogenic reproductive stage had the lowest transcriptomic variability compared to other reproductive stages. This variability was lower in a single-spawning species (largemouth bass) compared to a multiple-spawner (fathead minnow). Following this, a meta-analysis of 777 microarrays for multiple fish species was performed to determine the influence of breeding strategy and tissue type on transcriptomic variability. In this analysis, single-spawning fish showed lower gonadal and hepatic transcriptome variability compared to multiple-spawning species. Thus, these species may be more appropriate for sampling molecular endpoints in monitoring programs. Transcript variability was lowest in the brain, followed by the gonads and liver, which may reflect fewer morphological changes relative to these tissues. The results of this study should be used in conjunction with other experimental and sampling recommendations to optimize the use of molecular endpoints in regulatory ecotoxicology and environmental monitoring programs." @default.
• W2413257246 created "2016-06-24" @default.
• W2413257246 creator A5009909006 @default.
• W2413257246 creator A5022463943 @default.
• W2413257246 creator A5070857812 @default.
• W2413257246 creator A5085283857 @default.
• W2413257246 date "2016-09-01" @default.
• W2413257246 modified "2023-09-24" @default.
• W2413257246 title "The influence of breeding strategy, reproductive stage, and tissue type on transcript variability in fish" @default.
• W2413257246 cites W1888021570 @default.
• W2413257246 cites W1966097910 @default.
• W2413257246 cites W1976841572 @default.
• W2413257246 cites W1991164591 @default.
• W2413257246 cites W2000089305 @default.
• W2413257246 cites W2000849916 @default.
• W2413257246 cites W2002922627 @default.
• W2413257246 cites W2011153704 @default.
• W2413257246 cites W2016249178 @default.
• W2413257246 cites W2026843553 @default.
• W2413257246 cites W2027519924 @default.
• W2413257246 cites W2049936558 @default.
• W2413257246 cites W2093233505 @default.
• W2413257246 cites W2105041695 @default.
• W2413257246 cites W2116717043 @default.
• W2413257246 cites W2116782015 @default.
• W2413257246 cites W2141833953 @default.
• W2413257246 cites W2163330042 @default.
• W2413257246 cites W2170195945 @default.
• W2413257246 cites W2245162543 @default.
• W2413257246 cites W2429732176 @default.
• W2413257246 cites W286197082 @default.
• W2413257246 cites W4253283678 @default.
• W2413257246 doi "https://doi.org/10.1016/j.cbd.2016.05.005" @default.
• W2413257246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27325421" @default.
• W2413257246 hasPublicationYear "2016" @default.
• W2413257246 type Work @default.
• W2413257246 sameAs 2413257246 @default.
• W2413257246 citedByCount "4" @default.
• W2413257246 countsByYear W24132572462016 @default.
• W2413257246 countsByYear W24132572462017 @default.
• W2413257246 countsByYear W24132572462018 @default.
• W2413257246 crossrefType "journal-article" @default.
• W2413257246 hasAuthorship W2413257246A5009909006 @default.
• W2413257246 hasAuthorship W2413257246A5022463943 @default.
• W2413257246 hasAuthorship W2413257246A5070857812 @default.
• W2413257246 hasAuthorship W2413257246A5085283857 @default.
• W2413257246 hasConcept C104317684 @default.
• W2413257246 hasConcept C126322002 @default.
• W2413257246 hasConcept C150194340 @default.
• W2413257246 hasConcept C162317418 @default.
• W2413257246 hasConcept C186836561 @default.
• W2413257246 hasConcept C54355233 @default.
• W2413257246 hasConcept C60644358 @default.
• W2413257246 hasConcept C70721500 @default.
• W2413257246 hasConcept C71924100 @default.
• W2413257246 hasConcept C78458016 @default.
• W2413257246 hasConcept C86803240 @default.
• W2413257246 hasConcept C90856448 @default.
• W2413257246 hasConcept C95190672 @default.
• W2413257246 hasConceptScore W2413257246C104317684 @default.
• W2413257246 hasConceptScore W2413257246C126322002 @default.
• W2413257246 hasConceptScore W2413257246C150194340 @default.
• W2413257246 hasConceptScore W2413257246C162317418 @default.
• W2413257246 hasConceptScore W2413257246C186836561 @default.
• W2413257246 hasConceptScore W2413257246C54355233 @default.
• W2413257246 hasConceptScore W2413257246C60644358 @default.
• W2413257246 hasConceptScore W2413257246C70721500 @default.
• W2413257246 hasConceptScore W2413257246C71924100 @default.
• W2413257246 hasConceptScore W2413257246C78458016 @default.
• W2413257246 hasConceptScore W2413257246C86803240 @default.
• W2413257246 hasConceptScore W2413257246C90856448 @default.
• W2413257246 hasConceptScore W2413257246C95190672 @default.
• W2413257246 hasFunder F4320334593 @default.
• W2413257246 hasLocation W24132572461 @default.
• W2413257246 hasLocation W24132572462 @default.
• W2413257246 hasOpenAccess W2413257246 @default.
• W2413257246 hasPrimaryLocation W24132572461 @default.
• W2413257246 hasRelatedWork W1678030323 @default.
• W2413257246 hasRelatedWork W2054198239 @default.
• W2413257246 hasRelatedWork W2055117508 @default.
• W2413257246 hasRelatedWork W2119884047 @default.
• W2413257246 hasRelatedWork W2126673251 @default.
• W2413257246 hasRelatedWork W2415870849 @default.
• W2413257246 hasRelatedWork W2799889211 @default.
• W2413257246 hasRelatedWork W2898442208 @default.
• W2413257246 hasRelatedWork W2981403185 @default.
• W2413257246 hasRelatedWork W3095610875 @default.
• W2413257246 isParatext "false" @default.
• W2413257246 isRetracted "false" @default.
• W2413257246 magId "2413257246" @default.
• W2413257246 workType "article" @default.