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• W2413272897 startingPage "5914" @default.
• W2413272897 abstract "The role of GABAergic signaling in establishing a critical period for experience in visual cortex is well understood. However, the effects of early experience on GABAergic synapses themselves are less clear. Here, we show that monocular deprivation (MD) during the adolescent critical period produces marked enhancement of GABAergic signaling in layer 2/3 of mouse monocular visual cortex. This enhancement coincides with a weakening of glutamatergic inputs, resulting in a significant reduction in the ratio of excitation to inhibition. The potentiation of GABAergic transmission arises from both an increased number of inhibitory synapses and an enhancement of presynaptic GABA release from parvalbumin- and somatostatin-expressing interneurons. Our results suggest that augmented GABAergic inhibition contributes to the experience-dependent regulation of visual function. SIGNIFICANCE STATEMENT Visual experience shapes the synaptic organization of cortical circuits in the mouse brain. Here, we show that monocular visual deprivation enhances GABAergic synaptic inhibition in primary visual cortex. This enhancement is mediated by an increase in both the number of postsynaptic GABAergic synapses and the probability of presynaptic GABA release. Our results suggest a contributing mechanism to altered visual responses after deprivation." @default.
• W2413272897 created "2016-06-24" @default.
• W2413272897 creator A5010584775 @default.
• W2413272897 creator A5031151569 @default.
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• W2413272897 date "2016-06-01" @default.
• W2413272897 modified "2023-09-30" @default.
• W2413272897 title "Visual Deprivation During the Critical Period Enhances Layer 2/3 GABAergic Inhibition in Mouse V1" @default.
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• W2413272897 doi "https://doi.org/10.1523/jneurosci.0051-16.2016" @default.
• W2413272897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4887562" @default.
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• W2413272897 hasPublicationYear "2016" @default.
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