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• W2413296873 abstract "Pathological Golgi fragmentation represents a constant pre-clinical feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) but its molecular mechanisms remain hitherto unclear. Here, we show that the severe Golgi fragmentation in transgenic mutant SOD1G85R and SOD1G93A mouse motor neurons is associated with defective polymerization of Golgi-derived microtubules, loss of the COPI coat subunit β-COP, cytoplasmic dispersion of the Golgi tether GM130, strong accumulation of the ER-Golgi v-SNAREs GS15 and GS28 as well as tubular/vesicular Golgi fragmentation. Data mining, transcriptomic and protein analyses demonstrate that both SOD1 mutants cause early presymptomatic and rapidly progressive up-regulation of the microtubule-destabilizing proteins Stathmins 1 and 2. Remarkably, mutant SOD1-triggered Golgi fragmentation and Golgi SNARE accumulation are recapitulated by Stathmin 1/2 overexpression but completely rescued by Stathmin 1/2 knockdown or the microtubule-stabilizing drug Taxol. We conclude that Stathmin-triggered microtubule destabilization mediates Golgi fragmentation in mutant SOD1-linked ALS and potentially also in related motor neuron diseases." @default.
• W2413296873 created "2016-06-24" @default.
• W2413296873 creator A5008323486 @default.
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• W2413296873 creator A5059510977 @default.
• W2413296873 date "2016-06-09" @default.
• W2413296873 modified "2023-10-17" @default.
• W2413296873 title "Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons" @default.
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• W2413296873 doi "https://doi.org/10.1186/s13024-016-0111-6" @default.
• W2413296873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4899909" @default.
• W2413296873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27277231" @default.
• W2413296873 hasPublicationYear "2016" @default.
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